Nelson W R, Taylor G A
Scand J Haematol. 1975 Aug;15(1):35-44. doi: 10.1111/j.1600-0609.1975.tb01053.x.
Citrated canine platelet rich plasma stimulated with ADP, thrombin, collagen and E. coli endotoxin demonstrated platelet aggregation when measured with Payton aggregometer. Following incubation with hydrocortisone sodium succinate (Solu-Cortef) the same platelet rich plasma did not undergo platelet aggregation when stimulated by these agents. Solu-Cortef added to platelet rich plasma during ATP, thrombin, collagen and endotoxin stimulated platelet aggregation resulted in a reversal of the optical density suggesting deaggregation. These in vitro observations support the beneficial effects observed when steroids are administered in vivo to experimental or clinical shock.
用ADP、凝血酶、胶原蛋白和大肠杆菌内毒素刺激的枸橼酸化犬富血小板血浆，在用佩顿血小板聚集仪测量时显示出血小板聚集。在用琥珀酸钠氢化可的松（氢化可的松注射液）孵育后，相同的富血小板血浆在受到这些试剂刺激时未发生血小板聚集。在ATP、凝血酶、胶原蛋白和内毒素刺激血小板聚集过程中，向富血小板血浆中添加氢化可的松注射液导致光密度逆转，提示解聚。这些体外观察结果支持了体内给予类固醇治疗实验性或临床休克时所观察到的有益效果。
