N-乙酰神经氨酸（唾液酸）对不同刺激诱导的血小板聚集的抑制作用。
Inhibition by N-acetyl neuraminic (sialic) acid of platelet aggregation induced by different stimuli.
作者信息
Kovács I B, Görög P
出版信息
Thromb Haemost. 1979 Dec 21;42(4):1187-92.
Addition of N-acetyl neuraminic acid (sialic acid, NANA) to citrated rat platelet-rich plasma significantly inhibited aggregation induced by near-threshold concentration of ADP, collagen or thrombin. In heparinized rat platelet-rich plasma aggregation of platelets induced by endotoxin or tumour cells of various origins was also inhibited by sialic acid. It is suggested that exogenous or endogenous sialic acid may act against various aggregating stimuli on the platelet membrane by masking a common factor through which various aggregating agents exert their effect.
向枸橼酸化的大鼠富血小板血浆中添加N-乙酰神经氨酸（唾液酸，NANA）可显著抑制接近阈浓度的ADP、胶原或凝血酶诱导的聚集。在肝素化的大鼠富血小板血浆中，内毒素或各种来源肿瘤细胞诱导的血小板聚集也受到唾液酸的抑制。提示外源性或内源性唾液酸可能通过掩盖各种聚集剂发挥作用的共同因子，从而对抗血小板膜上的各种聚集刺激。
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