来自云南红豆杉和东北红豆杉的紫杉烷二萜类化合物。

Taxane diterpenoids from Taxus yunnanensis and Taxus cuspidata.

作者信息

Shi Q W, Oritani T, Kiyota H, Zhao D

机构信息

Division of Life Science, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.

出版信息

Phytochemistry. 2000 Aug;54(8):829-34. doi: 10.1016/s0031-9422(00)00186-2.

DOI:10.1016/s0031-9422(00)00186-2

PMID:11014274

Abstract

Chemical examination of the seeds of the Chinese yew, Taxus runnanensis Cheng et L. K. Fu and the Japanese yew, Taxus cuspidata Sieb et Zucc, resulted in the isolation of four taxane diterpenoids. The structures of these taxoids were established as (12alpha)-2alpha-acetoxy-5alpha,9alpha, 10beta-trihydroxy-3,11-cyclotax-4(20)-en-13-one; 2alpha,7beta,13alpha-triacetoxy-5alpha, 9alpha-dihydroxy-2(3-->20)abeotaxa-4(20),11-dien-10-one; 9alpha,10beta-diacetoxy-5alpha-cinnamoyloxytaxa- 4(20),11-dien-13alpha-ol and the known 2alpha,7beta,9alpha,10beta,13-pentaacetoxytax a-4(20),12-diene-5alpha,11beta-diol on the basis of spectral analysis.

摘要

对中国红豆杉（云南红豆杉，Taxus runnanensis Cheng et L. K. Fu）和日本红豆杉（东北红豆杉，Taxus cuspidata Sieb et Zucc）的种子进行化学分析，结果分离出四种紫杉烷二萜类化合物。基于光谱分析，这些紫杉烷类化合物的结构被确定为（12α）-2α-乙酰氧基-5α,9α,10β-三羟基-3,11-环紫杉-4(20)-烯-13-酮；2α,7β,13α-三乙酰氧基-5α,9α-二羟基-2(3→20)去甲紫杉-4(20),11-二烯-10-酮；9α,10β-二乙酰氧基-5α-肉桂酰氧基紫杉-4(20),11-二烯-13α-醇以及已知的2α,7β,9α,10β,13-五乙酰氧基紫杉-4(20),12-二烯-5α,11β-二醇。