从日本红豆杉（Taxus cuspidata）叶子中分离出的三种新型紫杉烷类化合物。

Three new taxoids from the leaves of the Japanese yew, Taxus cuspidata.

作者信息

Shi Q W, Oritani T, Kiyota H, Murakami R

机构信息

Laboratory of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan.

出版信息

Nat Prod Lett. 2001;15(1):55-62. doi: 10.1080/10575630108041258.

DOI:10.1080/10575630108041258

PMID:11547424

Abstract

Three new taxane diterpenoids were isolated from the leaves of the Japanese yew, Taxus cuspidta. Their structures were established as 5 alpha,13 alpha-diacetoxy-taxa-4(20),11-diene-9 alpha,10 beta-diol (1), 7 beta,13 alpha-diacetoxy-5 alpha-cinnamyloxy-2(3-->20)-abeo-taxa-4(20),11-diene-2 alpha,10 beta-diol (2), and 2 alpha,10 beta,13 alpha-triacetoxy-taxa-4(20),11-diene-5 alpha,7 beta,9 alpha-triol (3) respectively on the basis of 1D and 2D NMR data.

摘要

从日本紫杉（Taxus cuspidta）的叶子中分离出了三种新的紫杉烷二萜类化合物。基于一维和二维核磁共振数据，它们的结构分别被确定为5α,13α-二乙酰氧基-紫杉-4(20),11-二烯-9α,10β-二醇（1）、7β,13α-二乙酰氧基-5α-肉桂酰氧基-2(3→20)-去甲-紫杉-4(20),11-二烯-2α,10β-二醇（2）和2α,10β,13α-三乙酰氧基-紫杉-4(20),11-二烯-5α,7β,9α-三醇（3）。