Chartier C, Etter E, Hoste H, Pors I, Koch C, Dellac B
AFSSA Niort, Laboratoire de recherches caprines, France.
Vet Res Commun. 2000 Sep;24(6):389-99. doi: 10.1023/a:1006474217064.
The spread of benzimidazole-resistant nematodes in dairy goat farms is of a great concern as probably more than 70% of the flocks are involved. As there are very few other anthelmintic options during the lactating period, we have evaluated the efficacy of copper oxide needles (CON, Copinox, Bayer, UK) in both experimental and natural infections in goats. The curative effect of CON (2-4 g) on existing worm burdens was assessed in goats experimentally infected with Teladorsagia circumcincta, Haemonchus contortus and Trichostrongyus colubriformis, compared to controls. The preventive effect of CON (4 g) on worm establishment was monitored for 2 months in animals experimentally infected with H. contortus and for 3 months in naturally infected animals on a farm exhibiting predominant infections with T. circumcincta and Oesophagostomum venulosum. In both experimental and natural conditions, the efficacy of CON was nil against Teladorsagia, Trichostrongylus and Oesophagostomum infections. In contrast, the efficacy of CON against Haemonchus was clearly established in reducing the worm burden (75%) as well as in lowering the egg output (37-95%) in relation to the establishment of new infections over several weeks. Copper oxide needles may represent an alternative to conventional anthelmintics in the control of Haemonchus infection in some goat farms.
苯并咪唑耐药性线虫在奶山羊养殖场的传播令人高度担忧，因为可能超过70%的羊群都受到了影响。由于在泌乳期几乎没有其他驱虫选择，我们评估了氧化铜针剂（CON，Copinox，拜耳，英国）在山羊实验性感染和自然感染中的疗效。将CON（2 - 4克）对现有蠕虫负荷的治疗效果在实验感染有环纹奥斯特线虫、捻转血矛线虫和蛇形毛圆线虫的山羊中进行评估，并与对照组进行比较。对CON（4克）对蠕虫定植的预防效果进行监测，在实验感染捻转血矛线虫的动物中监测2个月，在一个以环纹奥斯特线虫和微小食道口线虫为主的农场中对自然感染动物监测3个月。在实验和自然条件下，CON对奥斯特线虫、毛圆线虫和食道口线虫感染均无效。相比之下，CON对血矛线虫的疗效在减少蠕虫负荷（75%）以及在数周内降低新感染产生的虫卵产量（37 - 95%）方面得到了明确证实。在一些山羊养殖场，氧化铜针剂可能是控制血矛线虫感染的传统驱虫药的替代选择。
