Ceva Santé Animale, 10 Avenue de La Ballastière, 33500, Libourne, France.
Moredun Scientific, Pentlands Science Park (PSP), Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK.
Parasit Vectors. 2024 May 10;17(1):211. doi: 10.1186/s13071-024-06301-w.
The health and productivity of dairy goats continue to be impacted by gastrointestinal nematodes (GIN) and lungworms (LW). Eprinomectin (EPN) is frequently selected for treatment because it is generally effective and does not require a milk withdrawal period. However, some factors, such as lactation, can have an impact on EPN pharmacokinetics and potentially its efficacy. To evaluate whether this can alter the efficacy of Eprecis 2%, an eprinomectin injectable solution, a study was performed in lactating goats using the dose currently registered in cattle, sheep and goats (0.2 mg/kg).
This study was a blinded, randomized, controlled trial performed according to the VICH guidelines. Eighteen (18) worm-free lactating goats were included and experimentally challenged on day 28 with a mixed culture of infective gastrointestinal and lung nematode larvae (Haemonchus contortus, Trichostrongylus colubriformis, Teladorsagia circumcincta, Dictyocaulus filaria). At D-1, fecal samples were collected to confirm patent infection in all animals. On D0, the goats were randomly allocated into two groups of nine goats; group 1 was treated with Eprecis 2% at 0.2 mg/kg BW by subcutaneous injection, while group 2 remained untreated. Fecal samples for egg counts were collected from all animals on days 3, 5, 7, 9, 11 and 14. On D14, all goats were killed, and the abomasum, small intestine and lungs were removed, processed and subsampled to record the number and species of worms.
The treatment was well tolerated. After treatment, the arithmetic mean FEC decreased in the treated group and remained < 5 EPG until the end of the study, while the arithmetic mean FEC in the control group remained > 849.0 EPG. At D14, goats in the treated group had very limited or zero total worm counts, whereas all animals from the control group had a high worm burden. The measured efficacy was 100.0% against H. contortus and T. colubriformis, 99.9% against T. circumcincta and 98.0% against D. filaria.
Eprinomectin (Eprecis, 20 mg/ml), administered at the label dose (0.2 mg/kg), is highly effective against gastrointestinal nematodes and lungworms in lactating goats.
胃肠道线虫（GIN）和肺线虫（LW）继续影响奶山羊的健康和生产力。埃普菌素（EPN）因其通常有效且不需要牛奶撤出期而经常被选为治疗药物。然而，一些因素，如泌乳，可能会影响 EPN 的药代动力学及其潜在功效。为了评估这是否会改变 Eprecis 2%（一种埃普菌素注射溶液）的疗效，在泌乳山羊中进行了一项研究，使用了目前在牛、绵羊和山羊中注册的剂量（0.2mg/kg）。
这项研究是根据 VICH 指南进行的一项盲法、随机、对照试验。纳入 18 只无蠕虫泌乳山羊，并在第 28 天用混合感染的胃肠道和肺线虫幼虫（扭曲线虫、毛圆线虫、网尾线虫、丝状网尾线虫）进行实验性挑战。在 D-1，采集粪便样本以确认所有动物均有感染。在 D0，将山羊随机分为两组，每组 9 只；第 1 组用 Eprecis 2%按 0.2mg/kgBW 进行皮下注射，第 2 组未处理。所有动物于第 3、5、7、9、11 和 14 天采集粪便样本进行卵计数。在 D14，所有山羊被处死，取出皱胃、小肠和肺，进行处理和亚采样，以记录蠕虫的数量和种类。
治疗耐受性良好。治疗后，治疗组的算术平均 FEC 下降，直到研究结束时仍<5 EPG，而对照组的算术平均 FEC 仍>849.0 EPG。在 D14，治疗组的山羊总蠕虫计数非常有限或为零，而对照组的所有动物都有很高的蠕虫负担。测量的疗效对扭曲线虫和毛圆线虫为 100.0%，对网尾线虫为 99.9%，对丝状网尾线虫为 98.0%。
埃普菌素（Eprecis，20mg/ml）按标签剂量（0.2mg/kg）给药，对泌乳山羊的胃肠道线虫和肺线虫非常有效。
