Shimizu K, Watanabe E, Hamanaka S, Onuma S, Nakano M, Yamazaki T, Higa M, Yamamuro W, Kiguchi E
Dept. of Internal Medicine, Saiseikai Kanagawaken Hospital.
Gan To Kagaku Ryoho. 2000 Sep;27(10):1565-8.
A 67-year-old woman presented to our hospital with a chief complaint of bloody sputum. A plain chest X-ray a CT scan revealed a tumor shadow 3 cm in size in the middle lobe of the right lung, multiple nodular shadows in the bilateral lung fields and enlarged hilar and mediastinal lymph nodes. A tumor biopsy done under bronchoscopy revealed poorly differentiated adenocarcinoma of the lungs (cT2N3M1). She was given two courses of combination therapy consisting of cisplatin (80 mg/m2) and vinorelbine (20 mg/m2). The primary tumor in the middle lobe of the right lung and the lung metastases were markedly reduced in size, and a complete response was obtained. The only adverse events were grade 4 neutropenia and grade 2 nausea and vomiting.
一名67岁女性因咯血痰为主诉前来我院就诊。胸部X线平片和CT扫描显示右肺中叶有一个3厘米大小的肿瘤阴影,双侧肺野有多个结节状阴影,肺门和纵隔淋巴结肿大。经支气管镜下肿瘤活检显示为肺低分化腺癌(cT2N3M1)。给予她两疗程由顺铂(80mg/m²)和长春瑞滨(20mg/m²)组成的联合治疗。右肺中叶的原发肿瘤和肺转移灶大小明显缩小,获得了完全缓解。唯一的不良事件是4级中性粒细胞减少和2级恶心呕吐。