Buckley P, Simpson R
Acta Anaesthesiol Scand Suppl. 1975;60:76-9.
Bupivacaine and etidocaine were compared in 0.375% and 0.5% solutions (without adrenaline) in a double-blind study in thoracic epidural analgesia following upper abdominal surgery. Special regard was taken to duration and adequacy of analgesia and changes in motor function. Duration of analgesia was roughly comparable for all four solutions. Bupivacaine 0.375% and etidocaine 0.5% seemed to be appropriate concentrations for adequate pain relief. Motor function, as assessed by changes in FVC, FEV1 and PEFR was not influenced to any greater extent. A progressive fall in FVC with successive injections, indicating increasing motor weakness, did not occur.
在一项针对上腹部手术后胸段硬膜外镇痛的双盲研究中，对布比卡因和依替卡因的0.375%和0.5%溶液（不含肾上腺素）进行了比较。特别关注了镇痛的持续时间和充分性以及运动功能的变化。所有四种溶液的镇痛持续时间大致相当。0.375%的布比卡因和0.5%的依替卡因似乎是实现充分疼痛缓解的合适浓度。通过用力肺活量（FVC）、第一秒用力呼气量（FEV1）和呼气峰值流速（PEFR）的变化评估的运动功能未受到更大程度的影响。连续注射后FVC没有逐渐下降，这表明没有出现运动无力加重的情况。
