Oosters M
Acta Anaesthesiol Belg. 1977;28(2):61-74.
The author reports the comparative effects of 2 local anesthetic agents injected into the epidural space: 1% etidocaine and 0.5% bupivacaine, both containing epinephrine (5 microgram/ml). Twenty ml of one of these solutions were administered under double-blind conditions to 40 patients undergoing orthopedic, urological, gynecological or general surgery. The onset of analgesia, as determined by the "pin-prick test" was more rapid after 1% etidocaine than after 0.5% bupivacaine. The duration of analgesia, the return of sensation and the extent and intensity of the sensory blockade were identical for both drugs. After etidocaine, motor block occurred more often, was more complete and developed more rapidly than after bupivacaine. The incidence of peroperative and postoperative complications was comparable in both groups.
1%依替卡因和0.5%布比卡因，二者均含有肾上腺素（5微克/毫升）。在双盲条件下，将其中一种溶液20毫升给予40例接受骨科、泌尿外科、妇科或普通外科手术的患者。通过“针刺试验”确定，1%依替卡因后的镇痛起效比0.5%布比卡因更快。两种药物的镇痛持续时间、感觉恢复情况以及感觉阻滞的范围和强度相同。使用依替卡因后，运动阻滞比使用布比卡因后更常发生、更完全且发展更快。两组围手术期和术后并发症的发生率相当。
