Favrelère S, Stadelmann-Ingrand S, Huguet F, De Javel D, Piriou A, Tallineau C, Durand G
EA 1223 CEReX, Faculté de Médecine et Pharmacie, Poitiers, France.
Neurobiol Aging. 2000 Sep-Oct;21(5):653-60. doi: 10.1016/s0197-4580(00)00170-6.
Morphological and biochemical alterations are associated with a progressive age-related cognitive deficit. Plasmenylethanolamine, the major brain plasmalogen, may be modified during aging because of a possible antioxidant role and involvement in synaptic transmission. Two- and 18-month-old rats were used to study the effect of aging on the levels and acyl composition of plasmenylethanolamine (PmE), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in the frontal cortex and hippocampus. Aging only reduced significantly the PE levels in the frontal cortex. In 18-month-old rats, the fatty acid composition of the three phospholipid classes studied showed an increase of monounsaturated fatty acid (18:1 n-9 and 20:1 n-9) and a decrease in polyunsaturated fatty acid (PUFAs), essentially docosahexaenoic acid (DHA). DHA was markedly decreased in hippocampus PE. DHA, but also arachidonic acid, were considerably lower in frontal cortex PmE. PS modifications were similar in both regions. Hippocampus and frontal cortex underwent specific age-induced modifications in PmE and PE acyl composition. This could produce different effects on the functional ability of these two structures involved in the processes of specific memorization.
形态学和生化改变与年龄相关的渐进性认知缺陷有关。血浆乙醇胺作为大脑中主要的缩醛磷脂，可能因具有抗氧化作用并参与突触传递而在衰老过程中发生改变。使用2月龄和18月龄大鼠研究衰老对额叶皮质和海马体中血浆乙醇胺（PmE）、磷脂酰乙醇胺（PE）和磷脂酰丝氨酸（PS）水平及酰基组成的影响。衰老仅显著降低了额叶皮质中的PE水平。在18月龄大鼠中，所研究的三种磷脂类别的脂肪酸组成显示单不饱和脂肪酸（18:1 n-9和20:1 n-9）增加，多不饱和脂肪酸（PUFAs）减少，主要是二十二碳六烯酸（DHA）。海马体PE中的DHA显著降低。额叶皮质PmE中的DHA以及花生四烯酸含量也显著降低。两个区域的PS改变相似。海马体和额叶皮质在PmE和PE酰基组成上经历了特定的年龄诱导改变。这可能对这两个参与特定记忆过程的结构的功能能力产生不同影响。
