Canellos G P, DeVita V T, Young R C, Chabner B A, Schein P S, Johnson R E
Br J Cancer Suppl. 1975 Mar;2:474-80.
The initial results of a randomized clinical trial comparing intensive cyclical combination chemotherapy (CVP) and total body radiation therapy in the treatment of advanced (Stage III and IV) lymphocytic lymphoma is presented. Sixty-five patients have been entered and randomized according to stage. Of the chemotherapy treated patients, (22/27 (81%) achieved a response with 55% complete responders. The radiation group or those treated with radiation 27/32 (84%) responded with 56% in complete response. There is no significant difference in overall survival between the two groups. Nodular lymphoma (44 patients) responds more often and has s significantly longer survival than diffuse lymphoma (21 patients). Approximately 50% of the complete remitters have relapsed but reinduction of disease control was possible in almost all cases.
本文介绍了一项随机临床试验的初步结果，该试验比较了强化周期性联合化疗（CVP）和全身放射治疗在晚期（III期和IV期）淋巴细胞淋巴瘤治疗中的效果。65例患者已入组并根据分期进行随机分组。在接受化疗的患者中，22/27（81%）获得缓解，其中55%为完全缓解者。放疗组或接受放疗的患者中，27/32（84%）获得缓解，其中56%为完全缓解。两组的总生存率无显著差异。结节性淋巴瘤（44例患者）的缓解率更高，生存期明显长于弥漫性淋巴瘤（21例患者）。约50%的完全缓解者复发，但几乎在所有病例中都可以再次诱导疾病得到控制。
