Conner B D, Bernard G R
Center for Lung Research, Vanderbilt University, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Clin Chest Med. 2000 Sep;21(3):563-87. doi: 10.1016/s0272-5231(05)70167-2.
Remarkable progress has been made in the past 10 years with regard to understanding the interplay of potent physiologic mediators in patients with acute lung injury. Because there are so many mediators and the interaction of these agents is complex, true insight into the process has been slow in coming. Clinical studies in ARDS, as well as sepsis, the leading cause of ARDS, have increased in number, size, and quality over this same period. Although none of these studies has produced an accepted new therapy for ARDS, each has laid the groundwork for more efficient and more elegant studies of the problem. The stage is now set for the real advances to be brought forward and put to rigorous, efficient clinical testing.
在过去10年里，对于急性肺损伤患者体内强效生理介质之间相互作用的理解取得了显著进展。由于介质众多且这些介质之间的相互作用复杂，对这一过程的真正洞察来得较为缓慢。在同一时期，关于急性呼吸窘迫综合征（ARDS）以及作为ARDS主要病因的脓毒症的临床研究，在数量、规模和质量上都有所增加。尽管这些研究均未产生被认可的ARDS新疗法，但每项研究都为更高效、更精准地研究该问题奠定了基础。现在，真正的进展即将被提出并接受严格、高效的临床检验。
