Cabot C, Masanés R, Bullo M, García-Lorda P, Fernández-López J A, Salas-Salvadó J, Alemany M
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain.
Endocr Res. 2000 Aug;26(3):465-76. doi: 10.3109/07435800009066180.
A group of obese women (BMI>27 kg/m2; N=73) was studied together with lean controls (BMI <27 kg/m2; N=25). Three groups were defined by the compliance with: BMI lower than 27 kg/m2, glycaemia lower than 5.5 mM and insulinaemia lower than 0.2 nM (controls, group 1, N=19). The subjects with BMI>27 kg/m2, glucose >5.5 mM and insulin >0.2 nM constituted group 3 (N=41), and those with BMI>27 with glycaemia and/or insulinaemia lower than the limits set constituted group 2 (N=32). The women in group 3 had higher fat content, BMI and fat-free mass than those in group 2 and the controls. There were no changes in most plasma parameters, such as free estrone and beta-estradiol. Leptin levels were higher in groups 2 and 3 than in controls. In controls, leptin and acyl-estrone levels were well correlated with BMI and fat content; this correlation was not found in groups 2 and 3 for acyl-estrone, although it was found for leptin. Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone. In obese women, acyl-estrone levels -and probably function- are lower than expected, contrasting with maintained leptin-BMI correlations. The role of insulin in the control of body weight, perhaps through acyl estrone-mediated effects, should be re-evaluated.
一组肥胖女性（体重指数>27kg/m²；N = 73）与瘦素对照组（体重指数<27kg/m²；N = 25）一起进行了研究。根据以下标准定义了三组：体重指数低于27kg/m²、血糖低于5.5mM且胰岛素血症低于0.2nM（对照组，第1组，N = 19）。体重指数>27kg/m²、血糖>5.5mM且胰岛素>0.2nM的受试者构成第3组（N = 41），体重指数>27但血糖和/或胰岛素血症低于设定限值的受试者构成第2组（N = 32）。第3组女性的脂肪含量、体重指数和去脂体重高于第2组和对照组。大多数血浆参数，如游离雌酮和β-雌二醇，没有变化。第2组和第3组的瘦素水平高于对照组。在对照组中，瘦素和酰基雌酮水平与体重指数和脂肪含量密切相关；在第2组和第3组中，酰基雌酮没有发现这种相关性，尽管瘦素存在这种相关性。与对照组相比，大多数肥胖女性的酰基雌酮水平低于预期，表明这种激素的可用性或功能发生了改变。在肥胖女性中，酰基雌酮水平——可能还有功能——低于预期，这与瘦素-体重指数相关性的维持形成对比。胰岛素在控制体重中的作用，可能是通过酰基雌酮介导的效应，应该重新评估。
