Nevin N C, Merrett J D
Br J Prev Soc Med. 1975 Jun;29(2):111-5. doi: 10.1136/jech.29.2.111.
This investigation is a direct attempt to test Renwick's (1972) hypothesis that 95% of anencephaly and spina bifida (ASB) is preventable by the avoidance of potatoes during pregnancy. Although the numbers involved in the study are small, the investigation fails to support the concept that short-term avoidance of potatoes before conception and throughout pregnancy in women who have had a previous ASB infant reduces the recurrence risk. In the potato-free group, of 23 pregnancies which went to term two infants had ASB (8-7%); whereas in the non-potato-free group, of 56 which went to term two infants had ASB (3-6%). The recurrence risk in both groups was about 5%. The incidence of ASB in the groups shows no significant difference (P = 0-58) and in the potato-free group was not reduced by 95% as postulated by Renwick.
本研究旨在直接验证伦威克（1972年）的假设，即95%的无脑儿和脊柱裂（ASB）可通过孕期避免食用土豆来预防。尽管该研究涉及的病例数较少，但研究结果并不支持这样的观点：曾生育过ASB患儿的女性，在受孕前及整个孕期短期避免食用土豆可降低复发风险。在无土豆组中，23例足月妊娠中有2例婴儿患ASB（8.7%）；而在非无土豆组中，56例足月妊娠中有2例婴儿患ASB（3.6%）。两组的复发风险均约为5%。两组中ASB的发病率无显著差异（P = 0.58），且无土豆组中ASB的发病率并未如伦威克所假设的那样降低95%。
