Hristova A, Lyons K, Tröster A I, Pahwa R, Wilkinson S B, Koller W C
Department of Neurology, University of Kansas Medical Center, Kansas City, USA.
Clin Neuropharmacol. 2000 Jul-Aug;23(4):208-11. doi: 10.1097/00002826-200007000-00007.
We studied the effect and temporal profile of deep brain stimulation (DBS) of the globus pallidus and subthalamic nucleus on the motor signs of Parkinson's disease (PD). Four patients with bilateral deep brain stimulators of the globus pallidus and four patients with bilateral deep brain stimulators of the subthalamus were studied while taking no medication and at 15 and 30 minutes and 1, 2, 4, and 6 hours after turning stimulation on. An immediate (15 minutes) and sustained (6 hours) benefit was observed for all the motor manifestations of PD for both stimulation sites. Deep brain stimulation of the globus pallidus and subthalamus is highly effective in reducing all the cardinal motor features of PD.
我们研究了苍白球和丘脑底核的深部脑刺激（DBS）对帕金森病（PD）运动症状的影响及时间特征。对4例双侧苍白球深部脑刺激患者和4例双侧丘脑底核深部脑刺激患者在未服用药物时以及开启刺激后15分钟、30分钟、1小时、2小时、4小时和6小时进行了研究。两个刺激部位对PD的所有运动表现均观察到即时（15分钟）和持续（6小时）的改善。苍白球和丘脑底核的深部脑刺激在减轻PD的所有主要运动特征方面非常有效。
