输精管切除术后男性对精子抗原的自身免疫反应。
Autoimmunity to sperm antigens in vasectomized men.
作者信息
Samuel T, Kolk A H, Rümke P, Van Lis J M
出版信息
Clin Exp Immunol. 1975 Jul;21(1):65-74.
Sera from vasectomized men were tested for the presence of antibodies directed against sperm antigens. A high percentage (about 55%) of the vasectomized men developed agglutinating antibodies. A lower percentage (22%) also developed low titres of antibodies to human protamine, as detected in the indirect IFT on swollen sperm heads and 22% developed cytotoxic antibodies. A correlation was found between the presence of anti-protamine antibodies and the presence of agglutinating and of cytotoxic antibodies. This correlation, and also the fact that they developed after vasectomy, indicates that the formation of antibodies against human protamine is a result of an autoimmune response to spermatozoa. The indirect IFT was also performed on 'normal' unswollen spermatozoa. All the sera were positive at least on one of the sperm antigens located in the acrosome, equator, or post-nuclear region, but no increase nor decrease in titre was found after vasectomy.
对接受输精管切除术男性的血清进行检测，以确定是否存在针对精子抗原的抗体。接受输精管切除术的男性中，有很高比例（约55%）产生了凝集抗体。较低比例（22%）的男性还产生了低滴度的抗人鱼精蛋白抗体，这在对肿胀精子头部进行的间接免疫荧光试验（IFT）中得以检测到，另有22%产生了细胞毒性抗体。抗鱼精蛋白抗体的存在与凝集抗体和细胞毒性抗体的存在之间存在相关性。这种相关性以及它们在输精管切除术后出现的事实表明，抗人鱼精蛋白抗体的形成是对精子的自身免疫反应的结果。还对“正常”未肿胀的精子进行了间接免疫荧光试验。所有血清至少对位于顶体、赤道或核后区域的一种精子抗原呈阳性，但输精管切除术后滴度未出现升高或降低。
Zotero 插件