Law H Y, Bodmer W F, Mathews J D, Skegg D C
Tissue Antigens. 1979 Aug;14(2):115-39. doi: 10.1111/j.1399-0039.1979.tb00830.x.
We examined 188 men who had undergone vasectomy up to 6 years previously and, for comparative purposes, 100 men who were about to undergo the operation. Blood specimens were available from a total of 283 men. Sperm antibody assays using immunofluorescence, microagglutination, and microimmobilization confirmed that the prevalance of several types of antibody is higher after vasectomy. Immobilizing and agglutinating antibodies appeared to be the most important. Trends in antibody prevalence according to the time after the operation were analyzed. Screening against lymphocytes and lymphoid lines showed that the anti-sperm activity of era was not related to anti-HLA or anti-Ia activity. Associations were examined between different types of sperm antibody, and between these antibodies and autoantibodies to other antigens. When antibody prevalence was studied in relation to HLA types, the HLA antigen A28 was found to be strongly associated with production of head agglutinating antibody (and immobilizing and immunofluorescent equatorial antibodies) after vasectomy. This is one of the first clear-cut examples of antibody production associated with the HLA system.
我们检查了188名在6年之前接受过输精管切除术的男性，为作比较，还检查了100名即将接受该手术的男性。总共获得了283名男性的血样。采用免疫荧光、微量凝集和微量制动法进行的精子抗体检测证实，输精管切除术后几种抗体的发生率较高。制动抗体和凝集抗体似乎最为重要。分析了术后不同时间抗体发生率的变化趋势。针对淋巴细胞和淋巴细胞系的筛查表明，血清的抗精子活性与抗HLA或抗Ia活性无关。研究了不同类型精子抗体之间以及这些抗体与其他抗原自身抗体之间的关联。在研究抗体发生率与HLA类型的关系时，发现HLA抗原A28与输精管切除术后头部凝集抗体（以及制动和免疫荧光赤道抗体）的产生密切相关。这是与HLA系统相关的抗体产生的首批明确实例之一。
