Samuel T, Crewe P R, Kolk A H, Rumke P, Barnes R D
Clin Exp Immunol. 1976 Jul;25(1):80-4.
Vasectomy induced anti-sperm antibodies in mice were seen to cross react with human spermatozoa. Similarly anti-sperm antibodies in an infertile human male subject were found not only to react with human but also with bovine, porcine and murine sperm. Both observations made with preparations of swollen spermatozoa demonstrate the cross-reactivity of anit-sperm protamine activity of different species. Therefore in spite of known species dependent differences in amino acid composition and sequence of protamines, they appear to have common antigenic determinants.
在小鼠中，输精管切除术诱导产生的抗精子抗体被发现可与人精子发生交叉反应。同样，在一名不育男性受试者体内发现的抗精子抗体不仅能与人精子反应，还能与牛、猪和小鼠的精子发生反应。这两项对肿胀精子制剂的观察均表明不同物种的抗精子鱼精蛋白活性具有交叉反应性。因此，尽管已知鱼精蛋白在氨基酸组成和序列上存在物种依赖性差异，但它们似乎具有共同的抗原决定簇。
