Mathews E S, Scrivani S J
Craniofacial Pain Center, and the Neurosurgical Service, Massachusetts General Hospital, Boston, USA.
Mt Sinai J Med. 2000 Sep;67(4):288-99.
Trigeminal neuralgia (TN) is the most common cephalic neuralgia in people over the age of fifty, with a mean incidence of 4 per 100,000. Percutaneous stereotactic differential radiofrequency thermal rhizotomy (RTR) is a well-recognized surgical treatment for TN. The purpose of this study was to evaluate a management algorithm for TN and to evaluate the effectiveness of RTR for TN after failure of pharmacologic management.
Two hundred and fifty-eight (258) patients underwent RTR from 1992-1996 and were prospectively evaluated. These patients were characterized by age, sex, side of the face and division(s) involved. Patients were evaluated for pain relief, recurrence requiring or not requiring re-operation, and the type and rate of complications. They were followed by serial clinical evaluation and telephone interview. Patients were grouped according to results: (A) Successful Result--excellent or good pain relief; (B) Unsuccessful Result--fair, poor or no pain relief. The RTR group was compared to historical controls. Follow-up ranged from 12-80 months (mean = 38 months).
At early follow-up (defined as median postoperative period up to 6 months), pain relief that was excellent or good (successful results) occurred in 224/258 (87%). At long-term follow-up (> 6 months) recurrence of tic pain required re-operation in 31 patients (12%). In 37 patients (14%), recurrence of tic pain did not require re-operation. Dysesthesia developed in 20 patients (8%); corneal analgesia developed in 8 patients (3%). "Anesthesia dolorosa" developed in 5 patients (2%) and was medically managed. At the conclusion of the long-term follow-up period, 214/258 patients (83%) had excellent to good pain relief (successful result). There were no mortalities, no significant morbidity and a low rate of minor complications.
With the use of this specific diagnostic and management algorithm, patients with TN can be successfully managed with RTR.
三叉神经痛(TN)是50岁以上人群中最常见的头部神经痛,平均发病率为每10万人中有4例。经皮立体定向差分射频热凝术(RTR)是一种公认的治疗TN的外科手术。本研究的目的是评估TN的管理算法,并评估药物治疗失败后RTR治疗TN的有效性。
1992年至1996年,258例患者接受了RTR手术,并进行了前瞻性评估。这些患者的特征包括年龄、性别、面部受累侧及分支。对患者的疼痛缓解情况、是否需要再次手术的复发情况以及并发症的类型和发生率进行评估。通过系列临床评估和电话访谈对患者进行随访。根据结果将患者分组:(A)成功结果——疼痛缓解良好或优秀;(B)失败结果——疼痛缓解一般、差或无缓解。将RTR组与历史对照组进行比较。随访时间为12至80个月(平均38个月)。
在早期随访(定义为术后中位时间至6个月)时,224/258例(87%)患者疼痛缓解良好或优秀(成功结果)。在长期随访(>6个月)时,31例患者(12%)抽搐性疼痛复发需要再次手术。37例患者(14%)抽搐性疼痛复发不需要再次手术。20例患者(8%)出现感觉异常;8例患者(3%)出现角膜感觉缺失。5例患者(2%)出现“痛性麻木”,通过药物治疗。在长期随访结束时,214/258例患者(83%)疼痛缓解良好至优秀(成功结果)。无死亡病例,无严重并发症,轻微并发症发生率低。
通过使用这种特定的诊断和管理算法,TN患者可以通过RTR成功治疗。