Department of Neurosurgery, Ankara University, Faculty of Medicine, Turkey.
Acta Neurochir (Wien). 2012 May;154(5):785-91; discussion 791-2. doi: 10.1007/s00701-012-1311-7. Epub 2012 Mar 6.
The objective of this study was to evaluate the effectiveness of percutaneous controlled radiofrequency trigeminal rhizotomy (RF-TR) in patients with bilateral trigeminal neuralgia (BTN). Patients were analyzed after RF-TR in terms of outcome, safety and complications.
Eighty-nine BTN patients underwent 186 RF-TR procedures. Eighty-seven patients had idiopathic trigeminal neuralgia (ITN) and two patients had multiple sclerosis (2.2%). Fifty-six (62.9%) were women and 33 (37.1%) were men. Ages ranged from 29 to 85 years. Anesthesia was administered at a determined optimal level, allowing patient cooperation for controlled and selective lesioning.
The mean follow-up period was 101.71 ± 77.7 months. Familial occurrence was seen in two (2.2%) patients. Synchronized pain was observed in 25 (28.2%) patients. Pain occurrence on the contralateral side was observed with an average duration of 124.7 ± 87.13 months. Fifty-four of the 89 patients underwent 146 RF-TR procedures for both sides and 35 underwent 40 RF-TR procedures for one side. Complete pain relief or partial satisfactory pain relief was achieved on the medically treated side in 35 patients. During follow-up, 36 patients required the second procedure and 7 required the third procedure. Acute pain relief was reported in 86 (96.6%) patients. Early (<6 months) pain recurrence was observed in 11 (12.3%) and late (>6 months) recurrence in 25 (28.0%) patients. Complications included diminished corneal reflex in four (2.1%) patients, keratitis in two (1.1%), masseter dysfunction in four (2.1%), dysesthesia in two (1.1%), and anesthesia dolorosa in one (0.5%).
RF-TR is an effective, selective, well-controlled, and effortlessly repeatable procedure for treating BTN, especially in the elderly, in terms of low morbidity and mortality rates and high rate of satisfactory pain relief.
本研究旨在评估经皮控制射频三叉神经根切断术(RF-TR)治疗双侧三叉神经痛(BTN)患者的有效性。对接受 RF-TR 治疗的患者进行疗效、安全性和并发症分析。
89 例 BTN 患者共行 186 次 RF-TR 手术。87 例为特发性三叉神经痛(ITN),2 例为多发性硬化症(2.2%)。56 例(62.9%)为女性,33 例(37.1%)为男性。年龄 29~85 岁。采用确定的最佳麻醉水平进行麻醉,允许患者配合进行可控和选择性病变。
平均随访时间为 101.71±77.7 个月。2 例(2.2%)患者有家族史。25 例(28.2%)患者有同步性疼痛。对侧疼痛的发生平均持续 124.7±87.13 个月。89 例患者中,54 例双侧共行 146 次 RF-TR 手术,35 例单侧行 40 次 RF-TR 手术。35 例患者经药物治疗后对侧疼痛完全缓解或部分缓解。随访过程中,36 例患者需要行第 2 次手术,7 例需要行第 3 次手术。86 例(96.6%)患者术后即刻疼痛缓解。11 例(12.3%)患者在术后 6 个月内出现早期疼痛复发,25 例(28.0%)患者在术后 6 个月后出现晚期疼痛复发。并发症包括 4 例(2.1%)角膜反射减弱,2 例(1.1%)角膜炎,4 例(2.1%)咀嚼肌功能障碍,2 例(1.1%)感觉异常,1 例(0.5%)痛觉过敏。
RF-TR 是一种有效、选择性强、易于控制且可重复进行的治疗 BTN 的方法,特别是对于老年患者,具有较低的发病率和死亡率以及较高的满意止痛率。