Brill Silviu, Ben-Abraham Ron, Goor-Aryeh Itay
Pain Clinic, Tel-Aviv Medical Center, Tel-Aviv, Israel.
Local Reg Anesth. 2010;3:155-7. doi: 10.2147/LRA.S14281. Epub 2010 Dec 12.
Trigeminal neuralgia (TGN) is a challenging pain syndrome.
To test the effectiveness of local instillation of ophthalmic solution of amethocaine in relieving the pain of TGN.
We performed an open-label prospective study in 40 consecutive currently treated patients suffering from TGN with a reported visual analog scale (VAS) >8 (severe pain). The patients received two drops of amethocaine 1% instilled on the cornea ipsilateral to the painful side. Pain score assessment using VAS was recorded pre- and post-treatment.
A total of 32 (80%) patients reported a significant reduction in pain 10 minutes after drops instillation as compared with pre-treatment pain score. Pre-treatment VAS score was 8.53 ± 0.6 as compared with 4.78 ± 1.83 post-amethocaine treatments (P < 0.00001).
Topical ophthalmic instillation of amethocaine 1% can be considered as an immediate effective method for pain paroxysm of TGN.
三叉神经痛（TGN）是一种具有挑战性的疼痛综合征。
测试丁卡因眼药水局部滴注缓解TGN疼痛的有效性。
我们对40例连续接受治疗的TGN患者进行了一项开放标签前瞻性研究，这些患者报告的视觉模拟量表（VAS）>8（重度疼痛）。患者在患侧角膜上滴入两滴1%丁卡因。使用VAS记录治疗前后的疼痛评分。
与治疗前疼痛评分相比，共有32例（80%）患者在滴入眼药水10分钟后报告疼痛显著减轻。治疗前VAS评分为8.53±0.6，丁卡因治疗后为4.78±1.83（P<0.00001）。
局部滴注1%丁卡因可被视为TGN疼痛发作的一种即时有效方法。
