Wiesmann M, Seidel G
Departments of Radiology, Medical University of Lübeck, Lübeck, Germany.
Stroke. 2000 Oct;31(10):2421-5. doi: 10.1161/01.str.31.10.2421.
Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data to analyze brain tissue perfusion.
In 13 healthy volunteers, 2 doses (0.5 and 1.5 mL) of Optison, a perfluoropropane-containing ultrasound contrast agent, were injected intravenously, and they produced a strong increase in echo enhancement in the brain parenchyma. The contrast agent was injected twice for ultrasound examination of both hemispheres. A total of 24 hemispheres per dose was available for further analysis. We used harmonic imaging for quantification of echo enhancement. Color-coded perfusion maps were calculated from the ultrasound data. In 1 subject, magnetic resonance images were obtained parallel to the orientation of the ultrasound scans.
After administration of both doses of Optison, it was possible to evaluate brain tissue perfusion in all 24 hemispheres. Subtraction of precontrast images and color coding enhanced the visualization of hemispheric perfusion. The epiphyseal gland, anterior interhemispheric fissure, third ventricle, and lateral fissure can be used as reliable anatomic landmarks. Artifacts caused by abrupt changes in thickness of the temporal bone are observed as signal-void streaks oriented from the ultrasound probe toward the cerebral midline.
Harmonic gray-scale imaging with Optison shows strong echo enhancement in the brain parenchyma. By calculating color-coded perfusion maps, it is possible to visualize human brain tissue perfusion at the patient's bedside.
可从超声谐波灰阶成像数据计算出彩色编码灌注图，以分析脑组织灌注情况。
对13名健康志愿者静脉注射两剂（0.5毫升和1.5毫升）含全氟丙烷的超声造影剂Optison，其使脑实质回声增强显著增加。造影剂分两次注射，用于对双侧半球进行超声检查。每剂共有24个半球可供进一步分析。我们使用谐波成像对回声增强进行定量分析。从超声数据计算出彩色编码灌注图。对1名受试者获取了与超声扫描方向平行的磁共振图像。
给予两剂Optison后，所有24个半球的脑组织灌注均得以评估。减去造影前图像并进行彩色编码增强了半球灌注的可视化。松果体、大脑半球间前裂、第三脑室和外侧裂可作为可靠的解剖标志。颞骨厚度突然变化所导致的伪像表现为从超声探头朝向脑中线的信号缺失条纹。
使用Optison的谐波灰阶成像显示脑实质有强烈的回声增强。通过计算彩色编码灌注图，可在患者床边实现对人脑组织灌注的可视化。
