Bergdahl M, Bergdahl J
Department of Odontology, Faculty of Medicine and Odontology, Umeå University, Sweden.
J Dent Res. 2000 Sep;79(9):1652-8. doi: 10.1177/00220345000790090301.
Medication and psychological processes may affect salivary flow and cause subjective oral dryness. The importance of these factors is unclear. The aim of this study was to evaluate the association of medication, anxiety, depression, and stress with unstimulated salivary flow and subjective oral dryness. We studied 1,202 individuals divided into three groups, and controls. Intake of medication was evaluated. Anxiety, depression, and stress were assessed. Unstimulated salivary flow < 0.1 mL/min and subjective oral dryness were significantly associated with age, female gender, intake of psychotropics, anti-asthmatics, and diuretics. Unstimulated salivary flow < 0.1 mL/min and no subjective oral dryness were significantly associated with age, intake of antihypertensives, and analgesics. Subjective oral dryness and unstimulated salivary flow > 0.1 mL/min were significantly associated with depression, trait anxiety, perceived stress, state anxiety, female gender, and intake of antihypertensives. Age and medication seemed to play a more important role in individuals with hyposalivation, and female gender and psychological factors in individuals with subjective oral dryness.
药物和心理过程可能会影响唾液分泌并导致主观口腔干燥。这些因素的重要性尚不清楚。本研究的目的是评估药物、焦虑、抑郁和压力与非刺激性唾液分泌及主观口腔干燥之间的关联。我们研究了1202名个体，分为三组及对照组。评估了药物摄入情况。对焦虑、抑郁和压力进行了评估。非刺激性唾液分泌<0.1 mL/分钟及主观口腔干燥与年龄、女性性别、精神药物、抗哮喘药和利尿剂的摄入显著相关。非刺激性唾液分泌<0.1 mL/分钟且无主观口腔干燥与年龄、抗高血压药和镇痛药的摄入显著相关。主观口腔干燥及非刺激性唾液分泌>0.1 mL/分钟与抑郁、特质焦虑、感知压力、状态焦虑、女性性别及抗高血压药的摄入显著相关。年龄和药物在唾液分泌减少的个体中似乎起更重要的作用，而女性性别和心理因素在有主观口腔干燥的个体中起更重要的作用。
