Sebestyén A, Gallai M, Knittel T, Ambrust T, Ramadori G, Kovalszky I
1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Cytokine. 2000 Oct;12(10):1557-60. doi: 10.1006/cyto.2000.0754.
Syndecan-1 and syndecan-2-two cell surface heparan sulfate proteoglycans-were described in normal human liver. Proteoglycans can modulate the effect of cytokines, and cytokines can influence the expression of proteoglycans. In the present work the regulatory effect of IL-1beta, IL-6, TNF-alpha, IFN-gamma and TGF-beta1 on syndecan-1 and syndecan-2 expression of hepatocytes, hepatoma cell lines, liver and skin fibroblasts has been studied. All cytokines were able to influence the steady state level of syndecan-1 and syndecan-2 mRNA. Their action was target cell specific resulting in either up- or downregulation except TGF-beta1 that was stimulatory in all cell types examined.
Syndecan-1和syndecan-2（两种细胞表面硫酸乙酰肝素蛋白聚糖）已在正常人类肝脏中被描述。蛋白聚糖可调节细胞因子的作用，而细胞因子可影响蛋白聚糖的表达。在本研究中，已对白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）和转化生长因子-β1（TGF-β1）对肝细胞、肝癌细胞系、肝和皮肤成纤维细胞中syndecan-1和syndecan-2表达的调节作用进行了研究。所有细胞因子均能够影响syndecan-1和syndecan-2 mRNA的稳态水平。它们的作用具有靶细胞特异性，导致上调或下调，除了TGF-β1在所有检测的细胞类型中均具有刺激作用。
