Bellido M, Martino R, Aventín A, Carnicer M J, Rubiol E, López O, Sierra J, Nomdedéu J F
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Haematologica. 2000 Oct;85(10):1083-6.
Lineage classification needs to be established before starting chemotherapy in acute leukemias. In some cases, mixed populations can be found and these are differentiated by antigenic expression patterns.
We report the case of a patient with acute myelogenous leukemia whose relapse was classified as T-acute lymphoblastic leukemia (T-ALL).
Flow cytometry analysis at diagnosis enabled us to identify a minor T-cell subclone which progressively increased and became dominant at relapse. There were no changes at cytogenetic and molecular levels.
This case illustrates the usefulness of multiparametric flow cytometry for assessing minor leukemic populations.
急性白血病在开始化疗前需要进行谱系分类。在某些情况下，可发现混合细胞群，这些细胞群通过抗原表达模式进行区分。
我们报告了一例急性髓性白血病患者，其复发时被分类为T细胞急性淋巴细胞白血病（T-ALL）。
诊断时的流式细胞术分析使我们能够识别出一个较小的T细胞亚克隆，该亚克隆在复发时逐渐增加并成为优势克隆。细胞遗传学和分子水平未发生变化。
该病例说明了多参数流式细胞术在评估微小白血病细胞群方面的实用性。
