Al-Qurashi Fat-hia, Owaidah Tarek, Iqbal Mohammed A, Aljurf Mahmoud
Department of Oncology, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia.
Cancer Genet Cytogenet. 2004 Apr 1;150(1):66-9. doi: 10.1016/j.cancergencyto.2003.08.007.
We report an unusual case of acute biphenotypic leukemia with trisomy 4. A 22-year-old woman presented with acute leukemia characterized by the presence of two cell populations (prothymocytic and myeloblastic). The leukemic cells were resistant to standard induction chemotherapy and were cleared from the bone marrow only after a salvage chemotherapy regimen. To our knowledge, this is the fourth reported case of acute biphenotypic leukemia with trisomy 4 and perhaps the first case with T-lineage markers and acute myelocytic leukemia.
我们报告了一例罕见的伴有4号染色体三体的急性双表型白血病病例。一名22岁女性患急性白血病，其特征为存在两种细胞群（前胸腺细胞和髓母细胞）。白血病细胞对标准诱导化疗耐药，仅在采用挽救化疗方案后才从骨髓中清除。据我们所知，这是第四例报告的伴有4号染色体三体的急性双表型白血病病例，可能也是首例具有T系标志物和急性髓细胞白血病的病例。
