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Ly抗原:小鼠脾细胞上T细胞功能的标志物。

Ly antigens: markers of T cell function on mouse spleen cells.

作者信息

Hirst J A, Beverley P C, Kisielow P, Hoffmann M K, Oettgen H F

出版信息

J Immunol. 1975 Dec;115(6):1555-7.

PMID:1102601
Abstract

By the use of Ly antisera and complement it is possible to remove subpopulations of mouse T cells from spleen cell suspension. It is shown that these Ly antisera are specific for the Ly alleles carried by the cells. Helper cells from primed or unprimed mice and cells which respond to Con A express Ly-1 antigen but little or no Ly-2 antigen (Ly-1+ phenotype) whereas cells which respond to PHA express both Ly-1 and Ly-2 antigens (Ly-1+2+ phenotype).

摘要

通过使用Ly抗血清和补体,可以从小鼠脾细胞悬液中去除T细胞亚群。结果表明,这些Ly抗血清对细胞所携带的Ly等位基因具有特异性。来自已致敏或未致敏小鼠的辅助性T细胞以及对刀豆蛋白A有反应的细胞表达Ly-1抗原,但几乎不表达或不表达Ly-2抗原(Ly-1+表型),而对PHA有反应的细胞则同时表达Ly-1和Ly-2抗原(Ly-1+2+表型)。

相似文献

1
Ly antigens: markers of T cell function on mouse spleen cells.Ly抗原:小鼠脾细胞上T细胞功能的标志物。
J Immunol. 1975 Dec;115(6):1555-7.
2
A monoclonal antibody that recognizes an Ly-6-linked antigen inhibits the generation of functionally active T cell subsets.一种识别Ly-6相关抗原的单克隆抗体可抑制功能活性T细胞亚群的产生。
J Immunol. 1985 Jul;135(1):63-72.
3
Ly-4.2: a cell membrane alloantigen of murine B lymphocytes. II. Functional studies.Ly-4.2:小鼠B淋巴细胞的一种细胞膜同种异体抗原。II. 功能研究。
J Immunol. 1975 Feb;114(2 pt 2):856-62.
4
The xenogeneic effect. I. Antigen and mitogen-stimulated human lymphocytes produce a non-antigen-specific factor which reconstitutes the antibody response of T cell-deficient mouse spleen cells.异种效应。I. 抗原和丝裂原刺激的人淋巴细胞产生一种非抗原特异性因子,该因子可重建T细胞缺陷小鼠脾细胞的抗体应答。
J Immunol. 1975 Nov;115(5):1295-1300.
5
Regulation of immune responses by T cell subsets. Role of helper and suppressor T cells in the development and expression of MHC-restricted antibody responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X responder)F1 spleen cells.T细胞亚群对免疫反应的调节。辅助性T细胞和抑制性T细胞在(应答者×应答者)F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10(GAT)的MHC限制性抗体反应的发生和表达中的作用。
J Immunol. 1986 Feb 15;136(4):1201-9.
6
Subpopulations of mouse spleen lymphocytes. I. Dissociation between the reactivities to different "non-specific" mitogens.小鼠脾淋巴细胞亚群。I. 对不同“非特异性”有丝分裂原反应性之间的分离
Immunology. 1974 Apr;26(4):787-95.
7
Possible involvement of Ly-1 B cells in the effector phase of IgG suppression mediated by suppressor T cell factor.Ly-1 B细胞可能参与抑制性T细胞因子介导的IgG抑制效应阶段。
J Mol Cell Immunol. 1987;3(3):167-75.
8
Investigations into the nature of Igh-V region-restricted T cell interactions by using antibodies to antigens on methylcholanthrene-induced sarcomas. I. Analysis of an Igh-V-restricted suppressor-inducer factor.利用针对甲基胆蒽诱导肉瘤上抗原的抗体对Igh-V区限制性T细胞相互作用的性质进行研究。I. Igh-V限制性抑制诱导因子的分析。
J Immunol. 1985 Mar;134(3):1665-72.
9
Characterization of mouse helper and suppressor T cell subsets separated by lectins.用凝集素分离的小鼠辅助性和抑制性T细胞亚群的特性分析
J Immunol. 1980 Nov;125(5):1928-32.
10
Ly and Ia phenotype of suppressor T cells induced by graft-vs.-host reaction.移植物抗宿主反应诱导的抑制性T细胞的Ly和Ia表型
Eur J Immunol. 1977 Oct;7(10):746-8. doi: 10.1002/eji.1830071019.

引用本文的文献

1
A sub-set of murine T lymphocytes forming rosettes with rabbit erythrocytes.与兔红细胞形成玫瑰花结的小鼠T淋巴细胞亚群。
Immunology. 1980 Oct;41(2):415-9.
2
The effect of the plant lectins phytohaemagglutinin and concanavalin A on human T cell populations bearing receptors for IgG and IgM.植物凝集素植物血凝素和伴刀豆球蛋白A对带有IgG和IgM受体的人T细胞群体的作用。
Clin Exp Immunol. 1980 Aug;41(2):372-9.
3
Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera.同种异体抗原诱导的T细胞增殖:应答细胞的Lyt表型及Lyt抗血清对增殖的阻断作用。
Proc Natl Acad Sci U S A. 1980 May;77(5):2890-4. doi: 10.1073/pnas.77.5.2890.
4
Lack of correlative enhancement of passive transfer of delayed-type hypersensitivity and antilisterial resistance when using concanavalin A-stimulated primed spleen cells.使用伴刀豆球蛋白A刺激的致敏脾细胞时,迟发型超敏反应的被动转移与抗李斯特菌抵抗力缺乏相关增强。
Infect Immun. 1983 Mar;39(3):1208-13. doi: 10.1128/iai.39.3.1208-1213.1983.
5
Positive selection of T-cell subsets. I. Proliferative responses of Lyt 2 separated thymocytes and splenic T cells.T细胞亚群的阳性选择。I. Lyt 2分离的胸腺细胞和脾T细胞的增殖反应。
Immunology. 1982 May;46(1):49-58.
6
Mouse T-cell tumour immunoglobulin. I. Antigenic properties and effects on T-cell responses.小鼠T细胞肿瘤免疫球蛋白。I. 抗原特性及其对T细胞应答的影响。
Immunology. 1976 Nov;31(5):827-35.
7
The Qa-1 antigenic system. Relation of Qa-1 phenotypes to lymphocyte sets, mitogen responses, and immune functions.Qa-1抗原系统。Qa-1表型与淋巴细胞集落、丝裂原反应及免疫功能的关系。
J Exp Med. 1978 Oct 1;148(4):963-73. doi: 10.1084/jem.148.4.963.
8
A comparative study on the humoral immune responses in germ-free and conventional mice.无菌小鼠和普通小鼠体液免疫反应的比较研究。
Immunology. 1977 Jan;32(1):43-8.
9
Acute lymphoblastic leukaemia of the B-cell type refractory to intensive chemotherapy.对强化化疗耐药的B细胞型急性淋巴细胞白血病
Clin Exp Immunol. 1978 Mar;31(3):448-55.
10
Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors.Ly 1、Ly 2、Thy 1和TL分化抗原在小鼠T细胞肿瘤上的表达。
J Exp Med. 1978 Apr 1;147(4):1267-79. doi: 10.1084/jem.147.4.1267.