无菌小鼠和普通小鼠体液免疫反应的比较研究。
A comparative study on the humoral immune responses in germ-free and conventional mice.
作者信息
Ohwaki M, Yasutake N, Yasui H, Ogura R
出版信息
Immunology. 1977 Jan;32(1):43-8.
Abstract
The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to DNP-BSA were lower than in conventional mice, but no difference was observed in the IgM response to SRBC or the IgM and IgG responses to DNP-lys-Ficoll. Further, the number of 0-bearing cells in the spleen was smaller, and the mitogenic response of spleen cells to PHA was lower in germ-free mice than in conventional mice. These observations suggest that T cells of germ-free mice remain functionally immature.
摘要
在无菌饲养和常规饲养的ICR小鼠中，研究了对绵羊红细胞（SRBC）、二硝基苯基赖氨酸-聚蔗糖（DNP-lys-Ficoll）和二硝基苯基化牛血清白蛋白（DNP-BSA）的空斑形成细胞（PFC）反应。在无菌小鼠中，对SRBC的IgG反应以及对DNP-BSA的IgM和IgG反应低于常规小鼠，但对SRBC的IgM反应或对DNP-lys-Ficoll的IgM和IgG反应未观察到差异。此外，无菌小鼠脾脏中含0细胞的数量较少，且脾脏细胞对PHA的促有丝分裂反应低于常规小鼠。这些观察结果表明，无菌小鼠的T细胞在功能上仍未成熟。
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本文引用的文献
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Maturation of the humoral immune response in mice.小鼠体液免疫反应的成熟
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Cell surface immunoglobulin. VII. Synthesis, shedding, and secretion of immunoglobulin by lymphoid cells of germ-free mice.细胞表面免疫球蛋白。VII。无菌小鼠淋巴细胞免疫球蛋白的合成、脱落及分泌
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