Kolbach D N, Remme J J, Bos W H, Jonkman M F, De Jong M C, Pas H H, van der Meer J B
Department of Dermatology, Academisch Ziekenhuis, Groningen, Velsen, The Netherlands.
Br J Dermatol. 1995 Jul;133(1):88-90. doi: 10.1111/j.1365-2133.1995.tb02498.x.
In 1986, Berk and Lorincz reported the efficacy of tetracycline and nicotinamide in the treatment of bullous pemphigoid (BP). In the present study of seven patients with BP, we found that a regimen of 2 g tetracycline combined with 2 g nicotinamide daily was effective in clearing the skin lesions. Total remission was achieved within 6-8 weeks, after which the dose was gradually tapered. The mean duration of therapy was 7 months. No effect on the titre of antibasement membrane antibodies was observed. The mode of action of this therapy is unknown.
1986年，伯克和洛林茨报道了四环素和烟酰胺治疗大疱性类天疱疮（BP）的疗效。在本项针对7例BP患者的研究中，我们发现每日2克四环素与2克烟酰胺联合使用的方案对清除皮肤损害有效。6 - 8周内实现了完全缓解，之后剂量逐渐减少。平均治疗持续时间为7个月。未观察到对基底膜抗体滴度的影响。该疗法的作用方式尚不清楚。
