四环素和烟酰胺成功控制大疱性类天疱疮。

Bullous pemphigoid successfully controlled by tetracycline and nicotinamide.

作者信息

Kolbach D N, Remme J J, Bos W H, Jonkman M F, De Jong M C, Pas H H, van der Meer J B

机构信息

Department of Dermatology, Academisch Ziekenhuis, Groningen, Velsen, The Netherlands.

出版信息

Br J Dermatol. 1995 Jul;133(1):88-90. doi: 10.1111/j.1365-2133.1995.tb02498.x.

DOI:10.1111/j.1365-2133.1995.tb02498.x

PMID:7669647

Abstract

In 1986, Berk and Lorincz reported the efficacy of tetracycline and nicotinamide in the treatment of bullous pemphigoid (BP). In the present study of seven patients with BP, we found that a regimen of 2 g tetracycline combined with 2 g nicotinamide daily was effective in clearing the skin lesions. Total remission was achieved within 6-8 weeks, after which the dose was gradually tapered. The mean duration of therapy was 7 months. No effect on the titre of antibasement membrane antibodies was observed. The mode of action of this therapy is unknown.

摘要

1986年，伯克和洛林茨报道了四环素和烟酰胺治疗大疱性类天疱疮（BP）的疗效。在本项针对7例BP患者的研究中，我们发现每日2克四环素与2克烟酰胺联合使用的方案对清除皮肤损害有效。6 - 8周内实现了完全缓解，之后剂量逐渐减少。平均治疗持续时间为7个月。未观察到对基底膜抗体滴度的影响。该疗法的作用方式尚不清楚。