Mastrangelo M J, Goepp C E, Patel Y A, Clark W H
Arch Dermatol. 1979 Jul;115(7):864-5.
Although neurofibromatosis and cutaneous melanoma are both diseases of neuroectodermal origin, reports of their association are rare. The case history of a patient with histologically documented neurofibromatosis and a nodular melanoma unrelated to a cafe-au-lait spot or congenital nevus is reported, and the literature reviewed. The appearance of only one patient with neurofibromatosis in a series of 900 patients with melanoma suggests that these diseases are probably not associated with greater frequency than that predicted by chance alone.
虽然神经纤维瘤病和皮肤黑色素瘤均为神经外胚层起源的疾病，但关于它们关联的报道却很罕见。本文报告了一例经组织学证实患有神经纤维瘤病且患有与咖啡牛奶斑或先天性痣无关的结节性黑色素瘤患者的病例史，并对相关文献进行了综述。在900例黑色素瘤患者系列中仅出现1例神经纤维瘤病患者，这表明这两种疾病的关联频率可能并不高于仅由偶然因素预测的频率。
