1型神经纤维瘤病患儿发生致命性恶性黑色素瘤。

Fatal malignant melanoma in a child with neurofibromatosis type 1.

作者信息

Bin Amer Yousef, Al-Khenaizan Sultan

机构信息

Division of Dermatology, Department of Medicine, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

出版信息

Int J Dermatol. 2007 Sep;46(9):967-70. doi: 10.1111/j.1365-4632.2007.03205.x.

DOI:10.1111/j.1365-4632.2007.03205.x

PMID:17822504

Abstract

Neurofibromatosis type 1 is an autosomal dominant disease and is considered one of the most commonly inherited diseases in humans. Malignant melanoma has been reported in up to 5% of patients with neurofibromatosis type 1. We report a young Saudi boy with neurofibromatosis type 1 who developed fatal metastatic malignant melanoma arising from giant melanocytic nevi within speckled lentiginous nevus (SLN).

摘要

1型神经纤维瘤病是一种常染色体显性疾病，被认为是人类最常见的遗传性疾病之一。据报道，高达5%的1型神经纤维瘤病患者会发生恶性黑色素瘤。我们报告了一名患有1型神经纤维瘤病的沙特男孩，他因斑点状雀斑样痣（SLN）内的巨大黑素细胞痣发生致命性转移性恶性黑色素瘤。