Zhao D Y, Cioffi G A
Devers Eye Institute, Legacy Health System, Portland, Oregon, USA.
Eye (Lond). 2000 Jun;14 ( Pt 3B):445-9. doi: 10.1038/eye.2000.129.
The microvascular changes in the anterior optic nerve in human glaucomatous eyes were examined by selective methylmethacrylate microvascular corrosion castings following cannulation of the central retinal artery and posterior ciliary arteries in 11 normal eyes and 9 glaucomatous eyes. The resulting castings were examined with scanning electron microscopy. Microvascular changes were found in the anterior optic nerves of all the glaucomatous eyes with visual function loss. These findings include areas of capillary filling defects within the anterior optic nerve and a decreased numbers of feeding arteriolar vessels to the anterior optic nerve. In the prelaminar and laminar regions, the typical capillary patterns are lost and laminar striations are not present. Juxtapapillary choroidal and retinal avascular areas were also identified in two of the glaucomatous eyes. Selective microvascular corrosion casting is an excellent method to examine the three-dimensional microvasculature of the anterior optic nerve. Microvascular changes in the anterior optic nerve may play a role in the development of glaucomatous optic neuropathy.
通过对11只正常眼睛和9只青光眼眼睛的视网膜中央动脉和睫状后动脉进行插管后，采用选择性甲基丙烯酸甲酯微血管腐蚀铸型法，检查了人类青光眼眼中视神经前部的微血管变化。将所得铸型用扫描电子显微镜进行检查。在所有有视功能丧失的青光眼眼中，均发现视神经前部存在微血管变化。这些发现包括视神经前部的毛细血管充盈缺损区域以及供应视神经前部的小动脉血管数量减少。在筛板前和筛板区域，典型的毛细血管模式消失，且不存在筛板条纹。在两只青光眼眼中还发现了视乳头旁脉络膜和视网膜无血管区。选择性微血管腐蚀铸型法是检查视神经前部三维微血管系统的一种极佳方法。视神经前部的微血管变化可能在青光眼性视神经病变的发生发展中起作用。
