营养不良儿童的药物代谢：一项关于安替比林的研究。
Drug metabolism in malnourished children: a study with antipyrine.
作者信息
Homeida M, Karrar Z A, Roberts C J
出版信息
Arch Dis Child. 1979 Apr;54(4):299-302. doi: 10.1136/adc.54.4.299.
Abstract
The effect of malnutrition on hepatic drug-metabolising enzymes was investigated in 8 Sudanese children aged between 9 and 12.5 years using as a model the drug antipyrine. Antipyrine half-life and clearance were measured in the malnourished state and after 3 or 4 weeks of good nutrition. Associated with the improvement in nutritional state was a shortening of antipyrine half-life and an increase in its clearance. There was also a rise in serum triiodothyronine. It is concluded that poor nutrition is associated with impairment of drug metabolic capacity and that many factors are responsible.
摘要
以安替比林作为模型药物，对8名年龄在9至12.5岁之间的苏丹儿童进行研究，以探讨营养不良对肝脏药物代谢酶的影响。在营养不良状态下以及营养状况良好3或4周后，分别测定安替比林的半衰期和清除率。随着营养状况的改善，安替比林的半衰期缩短，清除率增加。血清三碘甲状腺原氨酸水平也有所升高。研究得出结论，营养不良与药物代谢能力受损有关，且涉及多种因素。
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