营养不良状态下磺胺异恶唑的动力学
Kinetics of sulphafurazole in undernutrition.
作者信息
Shastri R A
出版信息
Br J Clin Pharmacol. 1980 Nov;10(5):499-502. doi: 10.1111/j.1365-2125.1980.tb01795.x.
Abstract
1 An oral dose of 75 mg/kg body weight was used to study the kinetics of sulphafurazole in wellnourished and undernourished adult subjects. 2 There were no differences in the half-life, volume of distribution and total body clearance of the drug in the two groups of subjects. 3 The plasma protein binding of sulphafurazole was significantly reduced in the undernouished subjects. 4 It is concluded that alternations in the dosage schedule may not be necessary in the treatment of undernourished adults with sulphafurazole.
摘要
- 采用口服剂量为75毫克/千克体重的方法，研究了营养良好和营养不良的成年受试者体内磺胺异恶唑的动力学。2. 两组受试者中该药物的半衰期、分布容积和全身清除率没有差异。3. 营养不良受试者中磺胺异恶唑的血浆蛋白结合率显著降低。4. 得出的结论是，用磺胺异恶唑治疗营养不良的成年人时，可能无需改变给药方案。
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