乳腺癌的遗传易感性：HLA DQB*03032和HLA DRB1*11可能代表保护性等位基因。
Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.
作者信息
Chaudhuri S, Cariappa A, Tang M, Bell D, Haber D A, Isselbacher K J, Finkelstein D, Forcione D, Pillai S
机构信息
Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11451-4. doi: 10.1073/pnas.97.21.11451.
Abstract
Tumors are believed to emerge only when immune surveillance fails. We wished to ascertain whether the failure to inherit putative protective alleles of HLA class II genes is linked to the development of breast cancer. We molecularly typed HLA DPB1, DQB1, DRB1, and DRB3 alleles in 176 Caucasian women diagnosed with early-onset breast cancer and in 215 ethnically matched controls. HLA DQB03032 was identified in 7% of controls but in no patients with early-onset breast cancer (P = 0.0001). HLA DRB111 alleles were also significantly overrepresented (P < 0.0001) in controls (16. 3%) as compared with patients with early-onset breast cancer (3.5%). HLA DQB03032 and HLA DRB111 alleles may have a protective role in human breast cancer.
摘要
人们认为肿瘤只有在免疫监视功能失效时才会出现。我们希望确定未能遗传假定的HLA II类基因保护等位基因是否与乳腺癌的发生有关。我们对176名被诊断为早发性乳腺癌的白种女性以及215名种族匹配的对照者进行了HLA DPB1、DQB1、DRB1和DRB3等位基因的分子分型。在7%的对照者中发现了HLA DQB03032，但早发性乳腺癌患者中未发现（P = 0.0001）。与早发性乳腺癌患者（3.5%）相比，HLA DRB111等位基因在对照者（16.3%）中也显著富集（P < 0.0001）。HLA DQB03032和HLA DRB111等位基因可能对人类乳腺癌具有保护作用。
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本文引用的文献
1
On estimating the relation between blood group and disease.关于评估血型与疾病之间的关系。
Ann Hum Genet. 1955 Jun;19(4):251-3. doi: 10.1111/j.1469-1809.1955.tb01348.x.
2
Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.人类实体瘤逃避T细胞识别：分子机制与功能意义
Adv Immunol. 2000;74:181-273. doi: 10.1016/s0065-2776(08)60911-6.
3
Does HLA type predispose some individuals to cancer?
Mol Med Today. 1999 Aug;5(8):337-42. doi: 10.1016/s1357-4310(99)01524-5.
4
Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease.克罗恩病中MHC II类DP、DQ和DR等位基因的分析。
Gut. 1998 Aug;43(2):210-5. doi: 10.1136/gut.43.2.210.
5
Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer.BRCA1和BRCA2对早发性乳腺癌的不同贡献。
N Engl J Med. 1997 May 15;336(20):1416-21. doi: 10.1056/NEJM199705153362003.
6
An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.携带人类白细胞抗原（HLA）II类DRB3*0301等位基因的个体患克罗恩病的风险增加。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):5094-8. doi: 10.1073/pnas.93.10.5094.
7
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.犹太和非犹太早发性乳腺癌女性中的种系BRCA1突变
N Engl J Med. 1996 Jan 18;334(3):143-9. doi: 10.1056/NEJM199601183340302.
8
The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.酪氨酸酶基因编码一种抗原，该抗原可被HLA - A2黑色素瘤上的自体细胞溶解性T淋巴细胞识别。
J Exp Med. 1993 Aug 1;178(2):489-95. doi: 10.1084/jem.178.2.489.
9
Association between HLA-DQB1 alleles and risk for cervical cancer in African-American women.
Int J Cancer. 1994 May 15;57(4):504-7. doi: 10.1002/ijc.2910570411.
10
HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.人白细胞抗原DR-DQ与宫颈癌的关联具有乳头瘤病毒类型特异性。
Nat Genet. 1994 Feb;6(2):157-62. doi: 10.1038/ng0294-157.
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