Vedanarayanan V V, Chaudhry V
Department of Neurology, University of Mississippi School of Medicine, Jackson, USA.
Indian J Pediatr. 2000 Sep;67(9):635-46. doi: 10.1007/BF02762173.
Guillian Barré Syndrome (GBS) is an acquired disease of the peripheral nerves that is characterized clinically by rapidly progressing paralysis, areflexia, and albumino-cytological dissociation. It affects both genders, involves people of all ages, is reported worldwide, and in the post-polio era, it is the most common cause of an acute generalized paralysis. The clinical features are distinct and a history and an examination generally lead to a high suspicion of the diagnosis that can then be confirmed by supportive laboratory tests and electrodiagnostic studies. This review discusses the recent advances in understanding of the different variants of GBS such as acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN), and the Fisher syndrome. The clinical, electrodiagnostic criteria, immunopathogenesis, and management of GBS and its variants are discussed.
吉兰-巴雷综合征（GBS）是一种获得性周围神经疾病，其临床特征为迅速进展的瘫痪、反射消失和蛋白细胞分离。它影响男女两性，涉及所有年龄段的人群，在全球范围内均有报道，并且在脊髓灰质炎后时代，它是急性全身性瘫痪最常见的病因。其临床特征明显，病史和检查通常会高度怀疑该诊断，随后可通过支持性实验室检查和电诊断研究加以证实。本综述讨论了在理解GBS不同变体方面的最新进展，如急性炎症性脱髓鞘性多发性神经病（AIDP）、急性运动轴索性神经病（AMAN）、急性运动感觉轴索性神经病（AMSAN）和费希尔综合征。文中还讨论了GBS及其变体的临床、电诊断标准、免疫发病机制和治疗。
