Abuamara S, Louis J S, Guyard M F, Barbier-Frebourg N, Tocques S, Lechevallier J, Mallet E
Clinique chirurgicale infantile, hôpital Charles-Nicolle, Rouen, France.
Arch Pediatr. 2000 Sep;7(9):927-32. doi: 10.1016/s0929-693x(00)90005-8.
Kingella kingae is a Gram-negative bacillus which belongs to the Neisseriaceae family. Its involvement in osteoarticular infections is relatively recent.
We report eight cases of Kingella kingae osteoarticular infections that have been diagnosed at the paediatric surgical centre of Rouen University Hospital since October 1995. Six boys and two girls (mean age: 30.6 months) presented with osteomyelitis in six cases and arthritis in two. Only 75% of patients had a fever at time of diagnosis. The biological findings were slightly modified. All samples were obtained from blood, bone or joint fluid. These samples were systematically inoculated into a blood culture tube. Positive Kingella kingae culture was achieved in seven local samples and in one blood culture. All children received two antibiotics via intravenous injection while waiting for the bacteriologic results. Later, the antibiotic treatment (amoxycillin) was given per os. The mean duration of treatment was 33 days. Patients were given intravenous treatment for a period of only ten days. Six patients were followed up for a period of more than 18 months and outcome was always uneventful.
Kingella kingae is usually present in the nasopharyngeal mucosa and spreads in the blood due to various infections. Different types of Kingella kingae infection have been reported with a large frequency of osteoarticular infection.
This type of infection does not present any unusual characteristics as compared to other osteoarticular infections. Because of its antibiotic sensitivity treatment duration could be reduced. Kingella kingae is a fragile microbe and its culture is often difficult; therefore, it is important to use blood culture tubes to inoculate joint fluid and bone samples.
金氏金杆菌是一种革兰氏阴性杆菌，属于奈瑟菌科。它参与骨关节炎感染的情况相对较新。
我们报告了自1995年10月以来在鲁昂大学医院儿科外科中心诊断出的8例金氏金杆菌骨关节炎感染病例。6名男孩和2名女孩（平均年龄：30.6个月），其中6例为骨髓炎，2例为关节炎。诊断时只有75%的患者发热。生物学检查结果略有改变。所有样本均取自血液、骨骼或关节液。这些样本被系统地接种到血培养管中。在7份局部样本和1份血培养中获得了金氏金杆菌阳性培养结果。所有儿童在等待细菌学结果期间通过静脉注射接受了两种抗生素治疗。后来，口服抗生素治疗（阿莫西林）。平均治疗 duration为33天。患者仅接受了10天的静脉治疗。6例患者随访了18个月以上，结果均无异常。
金氏金杆菌通常存在于鼻咽黏膜中，并因各种感染而在血液中传播。已报告了不同类型的金氏金杆菌感染，骨关节炎感染的频率较高。
与其他骨关节炎感染相比，这种类型的感染没有任何异常特征。由于其抗生素敏感性，治疗 duration可以缩短。金氏金杆菌是一种脆弱的微生物，其培养往往很困难；因此，使用血培养管接种关节液和骨样本很重要。
