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因纽特人的骨矿物质含量——数据的系统综述

Bone mineral content among Inuit - a systematic review of data.

作者信息

Skjøth Jonas Bjørn, Hagens Therese Mygind, Fleischer Inuuteq, Laursen Mogens, Andersen Stig

机构信息

Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Department of Orthopaedic Surgery, Aalborg University Hospital, Aalborg, Denmark.

出版信息

Int J Circumpolar Health. 2025 Dec;84(1):2502249. doi: 10.1080/22423982.2025.2502249. Epub 2025 May 19.

DOI:10.1080/22423982.2025.2502249
PMID:40388636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12090282/
Abstract

Inuit are a distinct ethnic group living in an environment likely to influence calcium metabolism and skeletal health. Bone mineral content (BMC) is a marker of skeletal health and fracture risk. Age is a dominant risk factor for osteoporosis, emphasising the importance of skeletal health in the ageing Inuit populations. This systematic review aims to provide an overview of data on BMC among Inuit. We performed a systematic search for data on BMC among Inuit guided by an experienced librarian. The search identified 211 studies, of which six provided data on BMC among Inuit living in Alaska or Canada. In men/women, BMC peaked around the age of 25 years in distal radius at 1.55/1.07 g/cm2 and in distal ulna at 0.81/0.54 g/cm2. Diaphysis of ulna, humerus, and tibia peaked around 10 years later. The 23% to 30% sex differences in BMC were similar across studies. Age related changes were parallel to other populations. In conclusion, BMC in Inuit is presented for easy viewing and comparison. BMC was similar between Inuit populations, and sex and age-related differences were comparable to other populations. New scientific studies should update data, include spine and hip, describe bone structure, and consider fracture risk beyond BMC.

摘要

因纽特人是一个独特的民族，生活在可能影响钙代谢和骨骼健康的环境中。骨矿物质含量（BMC）是骨骼健康和骨折风险的一个指标。年龄是骨质疏松症的主要风险因素，这凸显了骨骼健康在老龄化因纽特人群中的重要性。本系统评价旨在概述因纽特人中关于BMC的数据。我们在一位经验丰富的图书馆员的指导下，对因纽特人中关于BMC的数据进行了系统检索。检索确定了211项研究，其中六项提供了居住在阿拉斯加或加拿大的因纽特人中关于BMC的数据。在男性/女性中，桡骨远端的BMC在25岁左右达到峰值，分别为1.55/1.07克/平方厘米，尺骨远端为0.81/0.54克/平方厘米。尺骨、肱骨和胫骨的骨干在大约10年后达到峰值。不同研究中BMC的23%至30%的性别差异相似。与年龄相关的变化与其他人群相似。总之，呈现了因纽特人的BMC以便于查看和比较。因纽特人群之间的BMC相似，性别和年龄相关差异与其他人群相当。新的科学研究应更新数据，纳入脊柱和髋部，描述骨结构，并考虑BMC之外的骨折风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/3a7612a25f98/ZICH_A_2502249_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/798d83580fe7/ZICH_A_2502249_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/1d84a0951491/ZICH_A_2502249_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/3a7612a25f98/ZICH_A_2502249_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/798d83580fe7/ZICH_A_2502249_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/1d84a0951491/ZICH_A_2502249_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0207/12090282/3a7612a25f98/ZICH_A_2502249_F0003_B.jpg

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New point-of-care calcaneal ultrasound densitometer (Osteosys BeeTLE) compared to standard dual-energy X-ray absorptiometry (DXA).新型即时跟骨超声骨密度仪（Osteosys BeeTLE）与标准双能 X 射线吸收法（DXA）比较。
Sci Rep. 2024 Mar 22;14(1):6898. doi: 10.1038/s41598-024-56787-8.
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Prevalence and clinical features of heart failure in Greenland.格陵兰岛心力衰竭的患病率和临床特征。
Int J Circumpolar Health. 2023 Dec;82(1):2178068. doi: 10.1080/22423982.2023.2178068.
3
The influence of Scandinavian presence on Greenlandic lactase persistence.
斯堪的纳维亚人对格陵兰乳糖持续存在的影响。
Scand J Gastroenterol. 2023 Apr;58(4):349-353. doi: 10.1080/00365521.2022.2139155. Epub 2022 Oct 28.
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Thyroid autoimmunity in Greenlandic Inuit.格陵兰因纽特人的甲状腺自身免疫
Eur Thyroid J. 2022 May 27;11(3):e220071. doi: 10.1530/ETJ-22-0071.
5
Who lives in care homes in Greenland? A nationwide survey of demographics, functional level, medication use and comorbidities.谁居住在格陵兰的养老院中？一项全国性的关于人口统计学、功能水平、用药情况和合并症的调查。
BMC Geriatr. 2021 Sep 18;21(1):500. doi: 10.1186/s12877-021-02442-0.
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Hip geometry in hip fracture patients in Greenland occurring over a 7.7-year period.在格陵兰发生的髋部骨折患者的髋部几何形状。
J Orthop Surg Res. 2021 May 25;16(1):335. doi: 10.1186/s13018-021-02482-7.
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Prevalence, incidence, mortality, and quality of care of diagnosed diabetes in Greenland.格陵兰被诊断为糖尿病的患病率、发病率、死亡率和护理质量。
Diabetes Res Clin Pract. 2020 Feb;160:107991. doi: 10.1016/j.diabres.2019.107991. Epub 2019 Dec 23.
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Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus.空腹血糖受损或患有2型糖尿病的因纽特女性，其前臂骨密度并未升高。
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Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials.骨密度变化与骨折风险降低：已发表试验的荟萃回归分析。
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