Xia Y, Sass C, Shen X, Siest G, Visvikis S
Centre de Médecine Préventive, Université Henri Poincaré-Nancy I, Unité INSERM 525, Vandoeuvre-lès-Nancy, France.
Clin Chem Lab Med. 2000 Jul;38(7):655-9. doi: 10.1515/CCLM.2000.094.
The association of apolipoprotein E concentration and common polymorphism (codons 112/158) with lipid and apolipoprotein concentrations was studied in two Chinese healthy population samples from Beijing (n=99) and Shanghai (n=67). Body mass index and apolipoproteins E and AI and triglyceride concentrations were significantly different between the two populations (0.001<p<0.05), but apolipoprotein E common allele frequencies were not significantly different. Apolipoprotein E concentration was independently associated with apolipoproteins B and AI, total cholesterol and triglyceride concentrations in the Beijing group, but only with total cholesterol and apolipoprotein AI concentrations in the Shanghai group. Apolipoprotein E polymorphism was significantly associated with apolipoproteins E and AI, and triglyceride concentrations in the Beijing subjects (0.001<p<0.01), whereas apolipoprotein E polymorphism was significantly related only to apolipoprotein E concentration in the Shanghai group (p<0.001). This preliminary study with a limited number of subjects shows that the relations between both apolipoprotein E genotypes and concentration with lipid traits are not the same in the two studied Chinese populations.
在来自北京（n = 99）和上海（n = 67）的两个中国健康人群样本中，研究了载脂蛋白E浓度和常见多态性（密码子112/158）与脂质及载脂蛋白浓度之间的关联。两个群体之间的体重指数、载脂蛋白E和AI以及甘油三酯浓度存在显著差异（0.001 < p < 0.05），但载脂蛋白E常见等位基因频率无显著差异。在北京组中，载脂蛋白E浓度与载脂蛋白B和AI、总胆固醇及甘油三酯浓度独立相关，但在上海组中仅与总胆固醇和载脂蛋白AI浓度相关。在北京受试者中，载脂蛋白E多态性与载脂蛋白E和AI以及甘油三酯浓度显著相关（0.001 < p < 0.01），而在上海组中，载脂蛋白E多态性仅与载脂蛋白E浓度显著相关（p < 0.001）。这项受试者数量有限的初步研究表明，在两个研究的中国群体中，载脂蛋白E基因型和浓度与脂质特征之间的关系并不相同。
