de la Fuente E G, Rodriguez-Peralto J L, Ortiz P L, Barrientos N, Vanaclocha F, Iglesias L
Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
Acta Derm Venereol. 2000 Jul-Aug;80(4):299-301. doi: 10.1080/000155500750012234.
Oral involvement is uncommon in cutaneous T-cell lymphomas and usually associated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. The immunophenotype was CD3+, CD4+, CD8-, CD30-. The second patient had a mycosis fungoides for 5 years when she developed lesions in the uvula and oropharynx. She was treated with polychemotherapy and she is alive 5 years after oral involvement. The immunophenotype was CD3+, CD4-, CD8+, CD30-. There are conflicting reports about the prognosis in the CD8+ phenotype. The present cases and the literature review seem to indicate that in oral involvement the CD8- phenotype is not associated with a worse prognosis than the CD4+ subtype. However, it is necessary to study new cases to confirm this statement.
口腔受累在皮肤T细胞淋巴瘤中并不常见，通常与预后不良相关。本文描述了2例新病例的临床病理和免疫组化结果，并进行文献复习。首例患者患蕈样肉芽肿10年，随后口腔组织出现病变。尽管接受了治疗，她6个月后仍死亡。免疫表型为CD3+、CD4+、CD8-、CD30-。第二例患者患蕈样肉芽肿5年，随后悬雍垂和口咽出现病变。她接受了多药化疗，口腔受累5年后仍存活。免疫表型为CD3+、CD4-、CD8+、CD30-。关于CD8+表型的预后存在相互矛盾的报道。目前的病例和文献复习似乎表明，在口腔受累中，CD8-表型与预后较差并无关联，并不比CD4+亚型更差。然而，有必要研究更多新病例以证实这一说法。
