Gregorakos L, Thomaides T, Stratouli S, Sakayanni E
Department of Respiratory Insufficiency, Chest Hospital of Athens, Greece.
Clin Auton Res. 2000 Aug;10(4):193-6. doi: 10.1007/BF02291355.
The aim of this study was to identify the effectiveness of clonidine in the recovery of patients with neuroleptic malignant syndrome and autonomic dysfunction, including blood pressure lability. Nine patients with neuroleptic malignant syndrome and autonomic dysfunction were treated with clonidine in the intensive care unit, according to a protocol, and the results were compared with those of seven patients with the same syndrome who were not treated with clonidine. Clonidine was administered until blood pressure stability was fully restored, and thereafter the dose was gradually reduced. There was a significant reduction in the duration of ventilation and stay in the intensive care unit in the clonidine group. Three patients from the nonclonidine group died. The data suggest that in the clonidine group, patients with neuroleptic malignant syndrome and autonomic dysfunction appear to have better and faster recovery, especially in blood pressure control, after intravenous clonidine treatment.
本研究的目的是确定可乐定在患有抗精神病药恶性综合征及自主神经功能障碍（包括血压不稳定）患者康复过程中的有效性。根据一项方案，9例患有抗精神病药恶性综合征及自主神经功能障碍的患者在重症监护病房接受了可乐定治疗，并将结果与7例未接受可乐定治疗的相同综合征患者的结果进行了比较。持续给予可乐定直至血压完全恢复稳定，此后逐渐减少剂量。可乐定组的通气时间和在重症监护病房的住院时间显著缩短。非可乐定组有3例患者死亡。数据表明，在可乐定组中，患有抗精神病药恶性综合征及自主神经功能障碍的患者在静脉注射可乐定治疗后，似乎恢复得更好、更快，尤其是在血压控制方面。
