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The Fourth Lilly Prize Lecture, University of Aberdeen, September 1980. The clinical pharmacology of clonidine and related central antihypertensive agents.第四届礼来奖讲座，阿伯丁大学，1980年9月。可乐定及相关中枢性抗高血压药物的临床药理学。
Br J Clin Pharmacol. 1981 Sep;12(3):295-302. doi: 10.1111/j.1365-2125.1981.tb01217.x.
2
Development of an animal model for the study of antihypertensive agents.用于抗高血压药物研究的动物模型的建立。
Proc West Pharmacol Soc. 1984;27:333-6.
3
Comparative haemodynamic effects of clonidine and guanfacine.可乐定与胍法辛的血流动力学比较效应
Arch Int Pharmacodyn Ther. 1978 Jan;231(1):148-56.
4
Studies on clonidine and guanfacine withdrawal after short term treatment in the rat.大鼠短期治疗后可乐定和胍法辛撤药的研究。
Arch Int Pharmacodyn Ther. 1982 Sep;259(1):112-8.
5
Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine.
J Pharmacol Exp Ther. 1980 Jan;212(1):58-63.
6
Drug therapy: clonidine, a new antihypertensive drug.药物治疗：可乐定，一种新型抗高血压药物。
N Engl J Med. 1975 Dec 4;293(23):1179-80. doi: 10.1056/NEJM197512042932306.
7
Centrally acting drugs in antihypertensive therapy.抗高血压治疗中的中枢性作用药物。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):5S-12S. doi: 10.1111/j.1365-2125.1980.tb04898.x.
8
[Use of clonidine in the prevention of alcohol withdrawal syndrome].可乐定在预防酒精戒断综合征中的应用
Minerva Med. 1989 Nov;80(11):1233-5.
9
Pharmacology of guanfacine.胍法辛的药理学
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):21S-24S. doi: 10.1111/j.1365-2125.1980.tb04900.x.
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The central hypotensive effect of clonidine. Studies in tetraplegic subjects.可乐定的中枢性降压作用。对四肢瘫痪患者的研究。
Clin Pharmacol Ther. 1977 Apr;21(4):375-81. doi: 10.1002/cpt1977214375.

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A comparative study evaluating the prophylactic efficacy of oral clonidine and tramadol for perioperative shivering in geriatric patients undergoing transurethral resection of prostate.一项比较研究，评估口服可乐定和曲马多对接受经尿道前列腺切除术的老年患者围手术期寒战的预防效果。
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Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management.药物过量治疗注意力缺陷多动障碍：临床表现、毒性机制及处理方法。
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Oral clonidine pretreatment prior to venous cannulation.静脉插管前口服可乐定预处理。
Anesth Prog. 2006 Summer;53(2):34-42. doi: 10.2344/0003-3006(2006)53[34:OCPPTV]2.0.CO;2.
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Why patients with Alzheimer's disease may show increased sensitivity to tropicamide eye drops: role of locus coeruleus.为何阿尔茨海默病患者可能对托吡卡胺滴眼液表现出更高的敏感性：蓝斑的作用
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5
Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers.莫达非尼是否会激活人类的蓝斑核？莫达非尼与可乐定对人类志愿者觉醒及自主神经功能影响的比较。
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6
The use of clonidine in the management of autonomic overactivity in neuroleptic malignant syndrome.可乐定在治疗抗精神病药恶性综合征中自主神经功能亢进方面的应用。
Clin Auton Res. 2000 Aug;10(4):193-6. doi: 10.1007/BF02291355.
7
Comparison of the effects of clonidine and yohimbine on pupillary diameter at different illumination levels.可乐定和育亨宾在不同光照水平下对瞳孔直径影响的比较。
Br J Clin Pharmacol. 2000 Jul;50(1):65-8. doi: 10.1046/j.1365-2125.2000.00225.x.
8
The first in vivo experience of the effects of the continuous intrathecal infusion of clonidine on the locus coeruleus in the regulation of cerebral blood flow: a TCD study.
Ital J Neurol Sci. 1997 Jun;18(3):139-44. doi: 10.1007/BF02048481.
9
Oral clonidine reduces postoperative PCA morphine requirements.口服可乐定可减少术后患者自控镇痛（PCA）时吗啡的用量。
Can J Anaesth. 1996 Sep;43(9):900-6. doi: 10.1007/BF03011802.
10
Clinical consequences of abrupt drug withdrawal.突然停药的临床后果。
Med Toxicol Adverse Drug Exp. 1987 Sep-Oct;2(5):367-82. doi: 10.1007/BF03259954.

本文引用的文献

1
Changes in blood pressure, heart rate, and sympathetic activity on abrupt withdrawal of tiamenidine (HOE 440) in essential hypertension.原发性高血压患者突然停用噻美尼定（HOE 440）后血压、心率及交感神经活动的变化
Eur J Clin Pharmacol. 1980 Nov;18(6):449-54. doi: 10.1007/BF00874654.
2
Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline.原发性高血压长期治疗后停用胍法辛。关于血压、血浆和尿去甲肾上腺素的观察。
Eur J Clin Pharmacol. 1981 Jan;19(1):19-24. doi: 10.1007/BF00558376.
3
Guanfacine: effects of long-term treatment and withdrawal.胍法辛：长期治疗及撤药的影响
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):183S-188S. doi: 10.1111/j.1365-2125.1980.tb04928.x.
4
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.胍法辛长期治疗高血压的临床经验。第二部分：胍法辛的不良反应。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):157S-164S. doi: 10.1111/j.1365-2125.1980.tb04924.x.
5
[Critical considerations on the method of action of 2-(2,6-dichlorophenylamino)-2-imidazoline-hydrochloride].[关于2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐作用方式的关键考量]
Arzneimittelforschung. 1966 Aug;16(8):1055-8.
6
Interaction of DOPA decarboxylase inhibitors with the effect of alpha-methyldopa on blood pressure and tissue monoamines in rats.多巴脱羧酶抑制剂与α-甲基多巴对大鼠血压及组织单胺类物质作用的相互影响。
Acta Pharmacol Toxicol (Copenh). 1969;27(2):135-48. doi: 10.1111/j.1600-0773.1969.tb00501.x.
7
Investigations into the mechanism of the hypotensive effect of 2-(2,6-dichlorphenylamino)-2-imidazoline-HCl.2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐降压作用机制的研究
Eur J Pharmacol. 1967 Dec;2(3):155-62. doi: 10.1016/0014-2999(67)90080-5.
8
Centrally mediated decrease in sympathetic tone induced by 2(2,6-dichlorophenylamino)-2 imidazoline (S.T. 155, Catapresan).2-(2,6-二氯苯基氨基)-2-咪唑啉（S.T.155，可乐宁）诱导的中枢介导的交感神经张力降低
Eur J Pharmacol. 1967 Nov;2(2):147-8. doi: 10.1016/0014-2999(67)90041-6.
9
Observations on the hypotensive action of "Catapres" (ST 155) in man.关于“可乐定”（ST 155）对人体降压作用的观察。
Med J Aust. 1968 Jan 20;1(3):87-91. doi: 10.5694/j.1326-5377.1968.tb27492.x.
10
Intravenous clonidine in hypertensive patients.高血压患者静脉注射可乐定
Clin Pharmacol Ther. 1973 Sep-Oct;14(5):847-51. doi: 10.1002/cpt1973145847.

The Fourth Lilly Prize Lecture, University of Aberdeen, September 1980. The clinical pharmacology of clonidine and related central antihypertensive agents.

作者信息

Reid J L

出版信息

Br J Clin Pharmacol. 1981 Sep;12(3):295-302. doi: 10.1111/j.1365-2125.1981.tb01217.x.

DOI:10.1111/j.1365-2125.1981.tb01217.x
PMID:7295459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1401811/
Abstract
摘要