Tissue reactions to some dental implant materials. An in vivo study in white rats.

In a 10 week experimental investigation the tissue reactions to implantation of standardised test pieces made of a polysilicone, Silastic, Tantalum, Titanium and a cobalt-chromium alloy, Vitallium, were studied in the white rat. After 2 weeks, polysilicone, Tantalum and Titanium caused slight reactions whilst a comparatively strong round cell infiltration was observed around the cobalt-chromium test pieces. After 10 weeks, no cellular infiltration was demonstrable around any of the implant materials. The now all appeared inert and were surrounded by a tough connective tissue.