Simons F E, Bierman C W, Sprenkle A C, Simons K J
Pediatrics. 1975 Nov;56(5 pt-2 suppl):916-8.
The efficacy of dyphlline in prevention of exercise-induced bronchospasm (EIB) was studied in seven subjects. A single 15 mg/kg dose of dyphylline 40 minutes prior to exercise prevented EIB as documented by a significantly smaller mean greatest percent decrease in forced expiratory volume in one second when compared to placebo. Mean serum dyphylline concentrations 40 minutes after a dose of 15 mg/kg were probably in the lower portion of the therapeutic range.
在七名受试者中研究了二羟丙茶碱预防运动诱发性支气管痉挛（EIB）的疗效。运动前40分钟给予单次15mg/kg剂量的二羟丙茶碱可预防EIB，与安慰剂相比，一秒用力呼气量的平均最大百分比下降显著更小，证明了这一点。给予15mg/kg剂量40分钟后的平均血清二羟丙茶碱浓度可能处于治疗范围的较低部分。
