Tinkelman D G, Cavanaugh M J, Cooper D M
Am Rev Respir Dis. 1976 Jul;114(1):87-94. doi: 10.1164/arrd.1976.114.1.87.
The ability of atropine to inhibit exercise-induced bronchospasm was evaluated in 18 children with chronic, perennial asthma. In 17 of 18 patients, exercise-induced bronchospasm was blocked by prior inhalation of 0.1 mg per kg of atropine sulfate, administered in a randomized single blind fashion. In 14 of these 17 patients, significant bronchodilatation occured after the combination of atropine and exercise. Placebo failed to inhibit exercise-induced bronchospasm in any patient. These results suggest that the parasympathetic nervous system has a role in the mediation of exercise-induced bronchospasm in children.
对18名患有慢性持续性哮喘的儿童评估了阿托品抑制运动诱发性支气管痉挛的能力。在18名患者中的17名中，预先以随机单盲方式吸入每公斤0.1毫克硫酸阿托品可阻断运动诱发性支气管痉挛。在这17名患者中的14名中，阿托品与运动联合后出现了显著的支气管扩张。安慰剂在任何患者中均未能抑制运动诱发性支气管痉挛。这些结果表明，副交感神经系统在儿童运动诱发性支气管痉挛的介导中起作用。
