Sprenkle A C, VanArsdel P P, Biermann C W
Pediatrics. 1975 Nov;56(5 pt-2 suppl):937-9.
Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.
运动诱发性哮喘被用于证明一种口山酮类物质，一种新型口服活性类色甘酸药物，在人体中具有显著活性。以双盲交叉方式研究了单次口服剂量8毫克/千克在给药后两小时和五小时的效果，在五小时时观察到运动后支气管痉挛受到显著抑制。似乎需要进一步研究以确定最佳剂量和临床疗效。
