DiMattio J, Hochwald G M, Malhan C, Wald A
Pflugers Arch. 1975 Sep 9;359(3):253-64. doi: 10.1007/BF00587383.
The effects of changes in serum osmolarity on the rate and osmolarity of bulk flow of fluid into the cerebral ventricles and on cortical white and grey matter water content were studied in cats. Bulk flow rates and osmolarities were measured during ventriculocisternal perfusion both before and after intravenous infusion of glucose solutions. Infusions of glucose in concentrations greater than 6% decreased fluid bulk flow rate and its osmolarity. Glucose in concentrations less than 6 percent increased fluid bulk flow rate and decreased its osmolarity. Bulk flow rate and serum osmolarity were found to be linearly related with a coefficient of osmotic flow of minus 0.835 mul/min per mOsm/l. At the extremes of induced serum osmolarities, (290 and 360 mOsm/l) bulk flow rate was either increased by 120 percent or completely inhibited. Effluent osmolarity also increased proportionately to serum osmolarity (0.338 mOsm/l per mOsm/l). When compared to controls, cortical grey and white matter water content increased by 1.9 percent and 2.9 percent, respectively, when the infused glucose concentration was 2.5 percent or less, and decreased by 1.8 percent and 2.9 percent when the concentration was 10 percent or more. The results of these experiments suggest that the increased bulk flow comes from the brain, rather then directly from the blood.
在猫身上研究了血清渗透压变化对液体流入脑室的速率和渗透压以及皮质白质和灰质含水量的影响。在静脉输注葡萄糖溶液前后，通过脑室池灌注测量液体的流量速率和渗透压。输注浓度大于6%的葡萄糖会降低液体流量速率及其渗透压。浓度小于6%的葡萄糖会增加液体流量速率并降低其渗透压。发现流量速率与血清渗透压呈线性关系，渗透流系数为-0.835微升/分钟每毫渗摩尔/升。在诱导的血清渗透压极值（290和360毫渗摩尔/升）时，流量速率要么增加120%，要么完全被抑制。流出液渗透压也与血清渗透压成比例增加（每毫渗摩尔/升增加0.338毫渗摩尔/升）。与对照组相比，当输注的葡萄糖浓度为2.5%或更低时，皮质灰质和白质含水量分别增加1.9%和2.9%，当浓度为10%或更高时，分别降低1.8%和2.9%。这些实验结果表明，增加的流量来自大脑，而不是直接来自血液。
