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[对人羧基血红蛋白的紫外线照射分子和电泳级分中发色团对血红素和珠蛋白成分的光损伤程度的评估]

[An assessment of the degree of chromophore photo damage to the heme and globin components in UV-irradiated molecules and electrophoretic fractions of human carboxyhemoglobin].

作者信息

Putintseva O V, Artiukhov V G, Kalaeva E A

机构信息

Voronezh State University, Russia.

出版信息

Radiats Biol Radioecol. 2000 Jul-Aug;40(4):439-45.

PMID:11031493
Abstract

The contribution of hem and globin components of electrophoretic fractions of UV-irradiated human carboxyhemoglobin to photodestruction of the protein was studied. The changes observed are the result of summation of some processes unequal in intensity and direction that take place in microheterogeneous media of photomodified protein. Photosensitivity of hemoproteid in electrophoretic fraction depends on apoprotein condition, whereas the hem photoresistance cannot be the evidence of the photostability of the whole molecule.

摘要

研究了紫外线照射后的人羧基血红蛋白电泳组分中的血红素和珠蛋白成分对该蛋白质光破坏的贡献。观察到的变化是在光修饰蛋白质的微非均相介质中发生的一些强度和方向不等的过程总和的结果。电泳组分中血红蛋白的光敏性取决于脱辅基蛋白的状态,而血红素的光抗性不能作为整个分子光稳定性的证据。

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