Electrophoretic separation of human embryonic globin demonstrates "alpha-thalassemia" in human leukemia cell line K562.

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作者信息

Alter B P, Goff S C

出版信息

Biochem Biophys Res Commun. 1980 Jun 16;94(3):843-8. doi: 10.1016/0006-291x(80)91311-x.

DOI:10.1016/0006-291x(80)91311-x

PMID:6930971

Abstract

摘要

相似文献

Electrophoretic separation of human embryonic globin demonstrates "alpha-thalassemia" in human leukemia cell line K562.

Biochem Biophys Res Commun. 1980 Jun 16;94(3):843-8. doi: 10.1016/0006-291x(80)91311-x.

Human embryonic zeta-globin chains in adult patients with alpha-thalassemias.成人α地中海贫血患者体内的人类胚胎ζ-珠蛋白链

Proc Natl Acad Sci U S A. 1984 Oct;81(19):6188-91. doi: 10.1073/pnas.81.19.6188.

Gel electrophoretic separation of globin chains.珠蛋白链的凝胶电泳分离

Prog Clin Biol Res. 1981;60:157-75.

[Molecular causes of thalassemia. I. Identification of globin mRNA in homozygous beta-thalassemia using complementary human globin DNA].[地中海贫血的分子病因。I. 使用互补的人珠蛋白DNA鉴定纯合β地中海贫血中的珠蛋白mRNA]

Mol Biol (Mosk). 1978 Jul-Aug;12(4):787-94.

Embryonic zeta-globin chains in adults: a marker for alpha-thalassemia-1 haplotype due to a greater than 17.5-kb deletion.成人中的胚胎ζ-珠蛋白链：一种因大于17.5 kb缺失导致的α地中海贫血-1单倍型的标志物。

N Engl J Med. 1986 Jan 9;314(2):76-9. doi: 10.1056/NEJM198601093140203.

New murine globin bands on electrophoresis may not be new globin chains.电泳上新出现的小鼠珠蛋白条带可能并非新的珠蛋白链。

Hemoglobin. 1982;6(5):517-22. doi: 10.3109/03630268209083764.

Unbalanced globin synthesis in bone marrow of beta-thalassemia heterozygotes.β地中海贫血杂合子骨髓中珠蛋白合成失衡。

Birth Defects Orig Artic Ser. 1987;23(5A):157-61.

[An assessment of the degree of chromophore photo damage to the heme and globin components in UV-irradiated molecules and electrophoretic fractions of human carboxyhemoglobin].[对人羧基血红蛋白的紫外线照射分子和电泳级分中发色团对血红素和珠蛋白成分的光损伤程度的评估]

Radiats Biol Radioecol. 2000 Jul-Aug;40(4):439-45.

Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes.β地中海贫血杂合子的分级成红细胞中的珠蛋白合成

J Clin Invest. 1975 Mar;55(3):567-78. doi: 10.1172/JCI107964.

Embryonic erythroid differentiation in the human leukemic cell line K562.人类白血病细胞系K562中的胚胎红细胞分化

Proc Natl Acad Sci U S A. 1981 Jan;78(1):348-52. doi: 10.1073/pnas.78.1.348.

引用本文的文献

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.K562 细胞株的高产及鉴定：α-珠蛋白基因的过表达克隆：自噬相关生物标志物的初步分析。

Genes (Basel). 2023 Feb 23;14(3):556. doi: 10.3390/genes14030556.

Erythroleukemia (K562) cells contain a functional beta-globin gene.红白血病（K562）细胞含有一个功能性β-珠蛋白基因。

Mol Cell Biol. 1984 Nov;4(11):2553-5. doi: 10.1128/mcb.4.11.2553-2555.1984.

Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.人类血红蛋白转换的分子机制：胚胎、胎儿及成人成红细胞中珠蛋白基因的选择性低甲基化与表达

Proc Natl Acad Sci U S A. 1983 Nov;80(22):6907-11. doi: 10.1073/pnas.80.22.6907.

Inducible transcription of five globin genes in K562 human leukemia cells.K562人白血病细胞中五个珠蛋白基因的可诱导转录。

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5515-9. doi: 10.1073/pnas.80.18.5515.

DNase I hypersensitivity in the gamma globin gene locus of K562 cells.K562细胞γ珠蛋白基因座中的DNA酶I超敏感性

Nucleic Acids Res. 1983 Sep 10;11(17):6065-77. doi: 10.1093/nar/11.17.6065.

Naturally occurring methylation inhibitor: DNA hypomethylation and hemoglobin synthesis in human K562 cells.天然存在的甲基化抑制剂：人K562细胞中的DNA低甲基化与血红蛋白合成

Mol Cell Biol. 1987 May;7(5):1759-63. doi: 10.1128/mcb.7.5.1759-1763.1987.

Differential expression of human globin genes introduced in K562 cells.导入K562细胞中的人类珠蛋白基因的差异表达。

EMBO J. 1985 Apr;4(4):927-31. doi: 10.1002/j.1460-2075.1985.tb03720.x.

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