霉酚酸酯联合自体角质形成细胞在透明质酸基质上移植治疗坏疽性脓皮病顽固性溃疡
Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix.
作者信息
Wollina U, Karamfilov T
机构信息
Department of Dermatology and Allergology Friedrich-Schiller-University of Jena, Germany.
出版信息
J Eur Acad Dermatol Venereol. 2000 May;14(3):187-90. doi: 10.1046/j.1468-3083.2000.00019.x.
Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immuno-suppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system.
坏疽性脓皮病有时病程顽固，对使用皮质类固醇和/或环孢素A的标准免疫抑制治疗无反应。在这些病例中，改善疼痛性溃疡是一项治疗挑战。我们报告一名17岁患有严重坏疽性脓皮病的男孩，使用霉酚酸酯和采用酯化透明质酸递送系统的自体角质形成细胞移植成功治愈。
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